Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 12/20 | 0.65 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.65 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.65 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.64 |
| ▸ | NT5E | P21589 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6657530 | 0.90 | ADORA3 (0.65) | ADORA3ADORA2AADORA1ADORA2BMEN1 | |
| SCHEMBL6664739 | 0.90 | ADORA3 (0.66) | ADORA3ADORA2AADORA1ADORA2BMEN1 | |
| SCHEMBL6660928 | 0.87 | ADORA3 (0.64) | ADORA3ADORA2AADORA1ADORA2BMEN1 | |
| SCHEMBL6660925 | 0.87 | ADORA3 (0.64) | ADORA3ADORA2AADORA1ADORA2BMEN1 | |
| SCHEMBL6665786 | 0.87 | ADORA3 (0.59) | ADORA3ADORA2AADORA1ADORA2BMEN1 | |
| SCHEMBL6659397 | 0.86 | ADORA3 (0.75) | ADORA3ADORA2AADORA1ADORA2BMEN1 | |
| SCHEMBL6659384 | 0.86 | ADORA3 (0.75) | ADORA3ADORA2AADORA1ADORA2BMEN1 | |
| SCHEMBL5393611 | 0.81 | ADORA3 (0.92) | ADORA3ADORA2AADORA1ADORA2BMEN1 | |
| SCHEMBL3956133 | 0.81 | ADORA3 (0.92) | ADORA3ADORA2AADORA1ADORA2BMEN1 | |
| SCHEMBL13454895 | 0.80 | ADORA3 (0.84) | ADORA3ADORA2AADORA1ADORA2BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030857-A2 | ADENOSINE A1 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2000-08-30 | — | — | EP | claimed |
| WO-1999024449-A2 | ADENOSINE A1 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 1999-05-20 | — | — | WO | claimed |
| EP-1457495-A1 | Adenosine A1 receptor agonists | GLAXO GROUP LIMITED (GB) | 2004-09-15 | — | — | EP | disclosed |
| EP-1030857-B1 | ADENOSINE A1 RECEPTOR AGONISTS | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | disclosed |
| US-6455510-B1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2002-09-24 | — | — | US | disclosed |
| EP-1030857-A2 | ADENOSINE A1 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2000-08-30 | — | — | EP | disclosed |
| WO-1999024449-A2 | ADENOSINE A1 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 1999-05-20 | — | — | WO | disclosed |