Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.50 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ADH5 | P11766 | 1/20 | 0.48 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.47 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5937360 | 0.90 | LDHA (0.65) | LDHANPC1RAB9ASMN1; SMN2MAP4K4 | |
| SCHEMBL18716552 | 0.84 | NPC1 (0.56) | LDHANPC1RAB9ASMN1; SMN2MAP4K4 | |
| SCHEMBL9021665 | 0.84 | KDM4E (0.61) | KDM4EALDH1A1HPGDHTTL3MBTL1 | |
| SCHEMBL9024311 | 0.83 | KDM4E (0.56) | KDM4EALDH1A1HPGDHTTL3MBTL1 | |
| SCHEMBL1550565 | 0.83 | EGLN1 (0.53) | LDHAMAP4K4P4HA1P4HTMKDM4E | |
| SCHEMBL13986853 | 0.82 | KDM4E (0.59) | KDM4EALDH1A1HPGDHTTL3MBTL1 | |
| SCHEMBL6687942 | 0.82 | KDM4E (0.51) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL30753641 | 0.81 | LDHA (0.81) | LDHANPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL28312333 | 0.81 | LDHA (0.81) | LDHANPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL9022425 | 0.81 | KDM4E (0.58) | MAP4K4KDM4EALDH1A1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004006923-A1 | ARYL PIPERIDINE DERIVATIVES AS INDUCERS OF LDL-RECEPTOR EXPRESSION FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA | GLAXO GROUP LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |