Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | PDE4A | P27815 | 3/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | PDE1A | P54750 | 1/20 | 0.54 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.54 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20989098 | 0.93 | POLB (0.56) | POLBHIF1ASMN1; SMN2ADORA2BRXFP1 | |
| SCHEMBL13986116 | 0.91 | POLB (0.59) | POLBHIF1ASMN1; SMN2ADORA2BRXFP1 | |
| SCHEMBL6660921 | 0.89 | KMT2A (0.54) | POLBHIF1ASMN1; SMN2ADORA2BRXFP1 | |
| SCHEMBL27482324 | 0.88 | POLB (0.56) | POLBHIF1ASMN1; SMN2ADORA2BRXFP1 | |
| SCHEMBL8656845 | 0.87 | POLB (0.55) | POLBHIF1ASMN1; SMN2ADORA2BRXFP1 | |
| SCHEMBL1945875 | 0.86 | KMT2A (0.69) | POLBHIF1ASMN1; SMN2ADORA2BRXFP1 | |
| SCHEMBL8656848 | 0.86 | POLB (0.59) | POLBHIF1ASMN1; SMN2ADORA2BRXFP1 | |
| SCHEMBL6665236 | 0.86 | KMT2A (0.51) | POLBHIF1ASMN1; SMN2ADORA2BRXFP1 | |
| SCHEMBL7608741 | 0.85 | POLB (0.53) | POLBHIF1ASMN1; SMN2ADORA2BRXFP1 | |
| SCHEMBL20989108 | 0.85 | PDE4A (0.57) | POLBHIF1ASMN1; SMN2ADORA2BRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1257552-B1 | XANTHINE DERIVATIVES, INTERMEDIATES AND USE FOR TREATING OSTEOPOROSIS | AVENTIS PHARMA SA (FR) | 2004-08-18 | — | — | EP | disclosed |