Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | PDE4A | P27815 | 2/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6665174 | 0.94 | KMT2A (0.46) | KMT2AMEN1PDE4APDE4BPDE4C | |
| SCHEMBL6661011 | 0.91 | POLB (0.50) | KMT2AMEN1PDE4APDE4BPDE4C | |
| SCHEMBL6661746 | 0.89 | KMT2A (0.44) | KMT2AMEN1PDE4APDE4BPDE4C | |
| SCHEMBL6663376 | 0.88 | KMT2A (0.49) | KMT2AMEN1PDE4APDE4BPDE4C | |
| SCHEMBL6662150 | 0.88 | KMT2A (0.45) | KMT2AMEN1PDE4APDE4BPDE4C | |
| SCHEMBL6659535 | 0.88 | LMNA (0.47) | KMT2AMEN1PDE4APDE4BPDE4C | |
| SCHEMBL6660040 | 0.88 | KMT2A (0.44) | KMT2AMEN1PDE4APDE4BPDE4C | |
| SCHEMBL7459561 | 0.87 | POLB (0.65) | KMT2AMEN1POLBHIF1AALDH1A1 | |
| SCHEMBL6662449 | 0.86 | POLB (0.59) | KMT2AMEN1PDE4APDE4BPDE4C | |
| SCHEMBL6660921 | 0.85 | KMT2A (0.54) | KMT2AMEN1PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1257552-B1 | XANTHINE DERIVATIVES, INTERMEDIATES AND USE FOR TREATING OSTEOPOROSIS | AVENTIS PHARMA SA (FR) | 2004-08-18 | — | — | EP | disclosed |
| EP-1257552-A1 | XANTHINE DERIVATIVES, INTERMEDIATES AND USE FOR TREATING OSTEOPOROSIS | Aventis Pharma S.A. (FR) | 2002-11-20 | — | — | EP | disclosed |
| WO-2001060824-A1 | XANTHINE DERIVATIVES, INTERMEDIATES AND USE FOR TREATING OSTEOPOROSIS | AVENTIS PHARMA S.A. (FR) | 2001-08-23 | — | — | WO | disclosed |