Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | JAK1 | P23458 | 2/20 | 0.47 |
| ▸ | TYK2 | P29597 | 2/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MIF | P14174 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7985717 | 0.79 | KMT2A (0.73) | KDM4EHPGDHSD17B10JAK2JAK1 | |
| SCHEMBL28045808 | 0.79 | MAPK10 (0.60) | KDM4EHPGDHSD17B10KMT2AMEN1 | |
| SCHEMBL10094592 | 0.79 | MAPK10 (0.60) | KDM4EHPGDHSD17B10PTGS1PTGS2 | |
| SCHEMBL28864027 | 0.78 | KMT2A (0.70) | KDM4EHPGDHSD17B10JAK2JAK1 | |
| SCHEMBL24181594 | 0.77 | KDM4E (0.48) | KDM4EHPGDHSD17B10MCL1JAK2 | |
| SCHEMBL29603900 | 0.77 | KDM4E (0.48) | KDM4EHPGDHSD17B10MCL1JAK2 | |
| SCHEMBL24388805 | 0.77 | KDM4E (0.48) | KDM4EHPGDHSD17B10JAK2JAK1 | |
| SCHEMBL27420834 | 0.76 | SMN1; SMN2 (0.55) | KDM4EHPGDHSD17B10KMT2AMEN1 | |
| SCHEMBL27564107 | 0.75 | JAK2 (0.46) | HPGDJAK2JAK1TYK2PTGS1 | |
| SCHEMBL10094184 | 0.75 | HPGD (0.48) | KDM4EHPGDHSD17B10KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100465173-C | Selective kinase inhibitors | CYTOPIA RES PTY LTD (AU) | 2009-03-04 | — | — | CN | disclosed |
| CN-1906190-A | Selective kinase inhibitors | CYTOPIA RES PTY LTD (AU) | 2007-01-31 | — | — | CN | disclosed |
| WO-2004004730-A2 | 2-AMINOPYRAZINE DERIVATIVES AS INHIBITORS OF CYCLIN DEPENDENT KINASES FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTEX TECHNOLOGY LIMITED (GB) | 2004-01-15 | — | — | WO | disclosed |