Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 19/20 | 0.48 |
| ▸ | MMP13 | P45452 | 15/20 | 0.48 |
| ▸ | MMP9 | P14780 | 14/20 | 0.48 |
| ▸ | MMP1 | P03956 | 13/20 | 0.48 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.44 |
| ▸ | MMP7 | P09237 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6662677 | 0.88 | ADAM17 (0.48) | ADAM17MMP13MMP9MMP1ADAM10 | |
| SCHEMBL3941381 | 0.87 | ADAM17 (0.51) | ADAM17MMP13MMP9MMP1ADAM10 | |
| SCHEMBL7322010 | 0.87 | ADAM17 (0.64) | ADAM17MMP13MMP9MMP1ADAM10 | |
| SCHEMBL7348471 | 0.87 | ADAM17 (0.64) | ADAM17MMP13MMP9MMP1ADAM10 | |
| SCHEMBL6662800 | 0.87 | ADAM17 (0.64) | ADAM17MMP13MMP9MMP1ADAM10 | |
| SCHEMBL6658500 | 0.87 | ADAM17 (0.64) | ADAM17MMP13MMP9MMP1ADAM10 | |
| SCHEMBL7323483 | 0.87 | ADAM17 (0.64) | ADAM17MMP13MMP9MMP1ADAM10 | |
| SCHEMBL3939291 | 0.87 | ADAM17 (0.47) | ADAM17MMP13MMP9MMP1ADAM10 | |
| SCHEMBL3939279 | 0.86 | ADAM17 (0.46) | ADAM17MMP13MMP9MMP1ADAM10 | |
| SCHEMBL3941378 | 0.85 | ADAM17 (0.51) | ADAM17MMP13MMP9MMP1ADAM10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147080-B1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | WYETH CORP (US) | 2004-07-21 | — | — | EP | claimed |