Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.66 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.66 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.66 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6662680 | 1.00 | ADORA1 (0.66) | ADORA1ADORA3ADORA2ADOT1L | |
| SCHEMBL5376478 | 0.87 | DOT1L (0.64) | ADORA1ADORA3ADORA2ADOT1L | |
| SCHEMBL5376488 | 0.87 | DOT1L (0.64) | ADORA1ADORA3ADORA2ADOT1L | |
| SCHEMBL6662994 | 0.87 | ADORA3 (0.71) | ADORA1ADORA3DOT1L | |
| SCHEMBL6663002 | 0.87 | ADORA3 (0.71) | ADORA1ADORA3DOT1L | |
| SCHEMBL5364283 | 0.87 | DOT1L (0.59) | ADORA1ADORA3DOT1L | |
| SCHEMBL5364270 | 0.87 | DOT1L (0.59) | ADORA1ADORA3DOT1L | |
| SCHEMBL21839554 | 0.81 | NT5E (0.61) | ADORA3DOT1L | |
| SCHEMBL9815315 | 0.80 | ADORA1 (0.62) | ADORA1ADORA3ADORA2ADOT1L | |
| SCHEMBL6688139 | 0.80 | ADORA1 (0.62) | ADORA1ADORA3ADORA2ADOT1L |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1457495-A1 | Adenosine A1 receptor agonists | GLAXO GROUP LIMITED (GB) | 2004-09-15 | — | — | EP | claimed |
| US-6455510-B1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2002-09-24 | — | — | US | claimed |
| EP-1030857-A2 | ADENOSINE A1 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2000-08-30 | — | — | EP | claimed |
| WO-1999024449-A2 | ADENOSINE A1 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 1999-05-20 | — | — | WO | claimed |
| EP-1457495-A1 | Adenosine A1 receptor agonists | GLAXO GROUP LIMITED (GB) | 2004-09-15 | — | — | EP | disclosed |
| EP-1030857-B1 | ADENOSINE A1 RECEPTOR AGONISTS | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | disclosed |
| US-6455510-B1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2002-09-24 | — | — | US | disclosed |
| EP-1030857-A2 | ADENOSINE A1 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2000-08-30 | — | — | EP | disclosed |
| WO-1999024449-A2 | ADENOSINE A1 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 1999-05-20 | — | — | WO | disclosed |