SCHEMBL6662836

SCHEMBL6662836

CC1(O)CCCC1Oc1ncc(Cl)cc1-c1cccc(S(C)(=O)=O)c1

nearest known ligand 0.61

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 8/20 0.61
PTGS1 P23219 6/20 0.39
FAAH O00519 1/20 0.37
OPRM1 P35372 1/20 0.37
OPRL1 P41146 1/20 0.37
LRRK2 Q5S007 1/20 0.36
SCN9A Q15858 2/20 0.35
SCN5A Q14524 1/20 0.35
PTK2 Q05397 1/20 0.35
APLNR P35414 1/20 0.35
HSD11B1 P28845 1/20 0.35
JAK2 O60674 1/20 0.35
CNR1 P21554 1/20 0.35
EPHB4 P54760 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6662831 0.89 PTGS2 (0.75) PTGS2PTGS1
SCHEMBL6660279 0.86 PTGS2 (0.82) PTGS2PTGS1FAAHOPRM1OPRL1
SCHEMBL6659481 0.84 PTGS2 (0.77) PTGS2PTGS1FAAHOPRM1OPRL1
SCHEMBL6659133 0.79 PTGS2 (0.58) PTGS2PTGS1HSD11B1EPHB4
SCHEMBL6664403 0.78 PTGS2 (0.72) PTGS2PTGS1
SCHEMBL6659905 0.76 PTGS2 (1.00) PTGS2PTGS1
SCHEMBL6661828 0.76 PTGS2 (1.00) PTGS2PTGS1
SCHEMBL8071875 0.75 PTGS2 (0.76) PTGS2PTGS1
SCHEMBL6658493 0.75 PTGS2 (0.65) PTGS2PTGS1FAAH
SCHEMBL6659480 0.73 PTGS2 (0.94) PTGS2PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1012142-B1 2,3,5-TRISUBSTITUTED PYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 MERCK FROSST CANADA INC (CA) 2004-08-11 EP claimed
US-6046217-A TREATING AN INFLAMMATORY DISEASE SUSCEPTIBLE TO TREATMENT WITH A NON-STEROIDAL ANTI-INFLAMMATORY AGENT COMPRISING ADMINISTERING TO A PATIENT IN NEED OF SUCH TREATMENT A NONTOXIC 3-PHENYL SUBSTITUTED PYRIDINES MERCK FROSST CANADA & CO. (CA) 2000-04-04 US claimed
EP-1012142-B1 2,3,5-TRISUBSTITUTED PYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 MERCK FROSST CANADA INC (CA) 2004-08-11 EP disclosed
EP-1012142-A1 2,3,5-TRISUBSTITUTED PYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 Merck Frosst Canada & Co. (CA) 2000-06-28 EP disclosed
US-6046217-A TREATING AN INFLAMMATORY DISEASE SUSCEPTIBLE TO TREATMENT WITH A NON-STEROIDAL ANTI-INFLAMMATORY AGENT COMPRISING ADMINISTERING TO A PATIENT IN NEED OF SUCH TREATMENT A NONTOXIC 3-PHENYL SUBSTITUTED PYRIDINES MERCK FROSST CANADA & CO. (CA) 2000-04-04 US disclosed
WO-1999014194-A1 2,3,5-TRISUBSTITUTED PYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2 MERCK FROSST CANADA & CO. (CA) 1999-03-25 WO disclosed