Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 19/20 | 0.58 |
| ▸ | AURKA | O14965 | 16/20 | 0.58 |
| ▸ | CD38 | P28907 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL665089 | 0.89 | RPS6KB1 (0.53) | RPS6KB1AURKACD38AURKB | |
| SCHEMBL663753 | 0.85 | RPS6KB1 (0.58) | RPS6KB1AURKAAURKB | |
| SCHEMBL665472 | 0.78 | RPS6KB1 (0.48) | RPS6KB1AURKAAURKB | |
| SCHEMBL664479 | 0.76 | RPS6KB1 (0.51) | RPS6KB1AURKAAURKB | |
| SCHEMBL665172 | 0.74 | RPS6KB1 (0.55) | RPS6KB1AURKAAURKB | |
| SCHEMBL665333 | 0.74 | RPS6KB1 (0.49) | RPS6KB1AURKAAURKB | |
| SCHEMBL664904 | 0.74 | RPS6KB1 (1.00) | RPS6KB1AURKAAURKB | |
| SCHEMBL666294 | 0.73 | RPS6KB1 (0.58) | RPS6KB1AURKACD38AURKB | |
| SCHEMBL665241 | 0.72 | AURKA (0.52) | RPS6KB1AURKAAURKB | |
| SCHEMBL686834 | 0.71 | RPS6KB1 (0.53) | RPS6KB1AURKACD38AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8637532-B2 | Amino azaheterocyclic carboxamides | MERCK PATENT GMBH (DE) | 2014-01-28 | — | — | US | disclosed |
| US-20120046269-A1 | Novel Amino Azaheterocyclic Carboxamides | MERCK PATENT GMBH (DE) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046269-A1 | Novel Amino Azaheterocyclic Carboxamides | AZI2, MKI67, MYC | RPS6KB1 500/4885AURKA 600/4885CD38 139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.