Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOXO1 | Q12778 | 14/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4912795 | 0.80 | FOXO1 (0.51) | FOXO1SIRT2SIRT1ACHENPC1 | |
| SCHEMBL4915117 | 0.72 | FOXO1 (0.49) | FOXO1ACHENPC1MEN1KMT2A | |
| SCHEMBL13373803 | 0.70 | FOXO1 (0.52) | FOXO1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL4910701 | 0.69 | NPC1 (0.52) | FOXO1ACHENPC1RAB9AMEN1 | |
| SCHEMBL4923449 | 0.69 | FOXO1 (0.54) | FOXO1ACHENPC1RAB9AMEN1 | |
| SCHEMBL22488738 | 0.69 | FOXO1 (0.74) | FOXO1ACHE | |
| SCHEMBL4923160 | 0.69 | KDM4E (0.54) | FOXO1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL4910663 | 0.69 | FOXO1 (0.55) | FOXO1ACHEMEN1KMT2AKDM4E | |
| SCHEMBL4913053 | 0.68 | NPC1 (0.52) | FOXO1ACHENPC1RAB9AMEN1 | |
| SCHEMBL4923470 | 0.67 | FOXO1 (0.48) | FOXO1ACHEMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441725-A1 | BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS | Aventis Pharmaceuticals Inc. (US) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003035065-A1 | BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS | AVENTIS PHARMACEUTICALS INC (US) | 2003-05-01 | — | — | WO | disclosed |