Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.80 |
| ▸ | MEN1 | O00255 | 1/20 | 0.80 |
| ▸ | GLA | P06280 | 1/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.75 |
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | KDM1A | O60341 | 5/20 | 0.60 |
| ▸ | SAT1 | P21673 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA3 | P07451 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL330921 | 0.93 | — | — | |
| SCHEMBL5932612 | 0.89 | CYP2C19 (1.00) | CYP2C19MEN1GLAKMT2ACYP1A2 | |
| SCHEMBL9241890 | 0.89 | CYP2C19 (1.00) | CYP2C19MEN1GLAKMT2ACYP1A2 | |
| Bis(Ethyl)Norspermine SCHEMBL429527 | 0.89 | CYP2C19 (1.00) | CYP2C19MEN1GLAKMT2ACYP1A2 | |
| SCHEMBL6899291 | 0.86 | CYP2C19 (1.00) | CYP2C19MEN1GLAKMT2ACYP1A2 | |
| Bis(Ethyl)Norspermine SCHEMBL5548459 | 0.86 | CYP2C19 (0.93) | CYP2C19MEN1GLAKMT2ACYP1A2 | |
| SCHEMBL7871599 | 0.86 | CYP2C19 (1.00) | CYP2C19MEN1GLAKMT2ACYP1A2 | |
| SCHEMBL4167237 | 0.86 | CYP2C19 (1.00) | CYP2C19MEN1GLAKMT2ACYP1A2 | |
| SCHEMBL4157457 | 0.86 | CYP2C19 (1.00) | CYP2C19MEN1GLAKMT2ACYP1A2 | |
| SCHEMBL12085576 | 0.86 | CYP2C19 (0.93) | CYP2C19MEN1GLAKMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1160267-B1 | CATALYST FOR OXIDATIVE POLYMERIZATION OF FLUOROPHENOL, METHOD OF OXIDATIVE POLYMERIZATION OF FLUOROPHENOL, AND POLY(OXYFLUOROPHENYLENE) DERIVATIVE | JAPAN SCIENCE & TECH CORP (JP) | 2004-08-04 | — | — | EP | disclosed |