Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 2/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1106901 | 0.92 | — | — | |
| SCHEMBL6660188 | 0.92 | CHRNA7 (0.46) | CHRNA7KDM4EALDH1A1MAPTPKM | |
| SCHEMBL13290580 | 0.92 | CHRNA7 (0.46) | CHRNA7KDM4EALDH1A1MAPTPKM | |
| SCHEMBL13290568 | 0.92 | CHRNA7 (0.46) | CHRNA7KDM4EALDH1A1MAPTPKM | |
| SCHEMBL681912 | 0.92 | CHRNA7 (0.46) | CHRNA7KDM4EALDH1A1MAPTPKM | |
| SCHEMBL6658443 | 0.88 | CHRNA7 (0.43) | CHRNA7KDM4EALDH1A1MAPTPKM | |
| SCHEMBL13290564 | 0.81 | CHRNA7 (0.40) | CHRNA7KDM4EALDH1A1MAPTPKM | |
| SCHEMBL840810 | 0.81 | CHRNA7 (0.40) | CHRNA7KDM4EALDH1A1MAPTPKM | |
| SCHEMBL13523626 | 0.81 | CHRNA7 (0.40) | CHRNA7KDM4EALDH1A1MAPTPKM | |
| SCHEMBL6657808 | 0.81 | CHRNA7 (0.40) | CHRNA7KDM4EALDH1A1MAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689919-B1 | SOLUBLE POLY(OXYFLUOROPHENYLENE) COMPOUNDS WITH EXCELLENT HEAT RESISTANCE, MEMBRANE-FORMABILITY AND CHEMICAL STABILITY | JAPAN SCIENCE AND TECHNOLOGY CORPORATION (JP) | 2004-02-10 | — | — | US | claimed |
| EP-1160267-B1 | CATALYST FOR OXIDATIVE POLYMERIZATION OF FLUOROPHENOL, METHOD OF OXIDATIVE POLYMERIZATION OF FLUOROPHENOL, AND POLY(OXYFLUOROPHENYLENE) DERIVATIVE | JAPAN SCIENCE & TECH CORP (JP) | 2004-08-04 | — | — | EP | disclosed |