Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | F12 | P00748 | 1/20 | 0.37 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CKS1B | P61024 | 1/20 | 0.36 |
| ▸ | SKP1 | P63208 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4038413 | 0.93 | NR1H2 (0.43) | NR1H2PARP1ESR2MAPK1KIT | |
| SCHEMBL4041722 | 0.85 | KIT (0.48) | NR1H2PARP1KITCSNK1EPOLB | |
| SCHEMBL4041973 | 0.79 | NR1H2 (0.45) | NR1H2PARP1ESR2F12PARP14 | |
| SCHEMBL31482 | 0.78 | NR1H2 (0.44) | NR1H2PARP1ESR2F12PARP14 | |
| SCHEMBL4037481 | 0.76 | GPR119 (0.40) | NR1H2PARP1F12KITPOLB | |
| SCHEMBL31481 | 0.75 | NR1H2 (0.42) | NR1H2PARP1ESR2CSNK1EGPR119 | |
| SCHEMBL4039705 | 0.74 | NR1H2 (0.42) | NR1H2ESR2MAPK1KITSCD5 | |
| SCHEMBL4039629 | 0.71 | USP2 (0.40) | NR1H2PARP1ESR2CSNK1EGPR119 | |
| SCHEMBL31445 | 0.70 | NR1H2 (0.44) | NR1H2PARP1ESR2F12PARP14 | |
| SCHEMBL4038552 | 0.69 | CSNK1E (0.52) | NR1H2CSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436291-A2 | INDOLIZINES AS KINASE PROTEIN INHIBITORS | Aventis Pharma S.A. (FR) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003024967-A2 | INDOLIZINES AS KINASE PROTEIN INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2003-03-27 | — | — | WO | disclosed |