Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.79 |
| ▸ | ERBB2 | P04626 | 11/20 | 0.79 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.74 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.74 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.74 |
| ▸ | ROS1 | P08922 | 1/20 | 0.74 |
| ▸ | FLT3 | P36888 | 1/20 | 0.74 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.74 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.74 |
| ▸ | HTT | P42858 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.68 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.68 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.60 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6664796 | 0.89 | HTT (0.67) | EGFRERBB2AURKBERBB4CHEK2 | |
| SCHEMBL1387244 | 0.88 | EGFR (1.00) | EGFRERBB2AURKBERBB4CHEK2 | |
| Hydrochloric Acid SCHEMBL8808379 | 0.87 | EGFR (0.98) | EGFRERBB2AURKBERBB4CHEK2 | |
| SCHEMBL7243965 | 0.87 | EGFR (0.79) | EGFRERBB2AURKBERBB4CHEK2 | |
| SCHEMBL8363497 | 0.87 | EGFR (1.00) | EGFRERBB2AURKBERBB4CHEK2 | |
| SCHEMBL1387160 | 0.87 | EGFR (0.73) | EGFRERBB2AURKBERBB4CHEK2 | |
| SCHEMBL1387147 | 0.87 | EGFR (0.79) | EGFRERBB2AURKBERBB4CHEK2 | |
| Hydrochloric Acid SCHEMBL7243031 | 0.86 | EGFR (0.77) | EGFRERBB2AURKBERBB4CHEK2 | |
| Hydrochloric Acid SCHEMBL8815263 | 0.86 | EGFR (0.72) | EGFRERBB2AURKBERBB4CHEK2 | |
| SCHEMBL3021044 | 0.86 | EGFR (0.77) | EGFRERBB2AURKBERBB4CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004013091-A2 | 4-ANILIDO SUBSTITUTED QUINAZOLINES AND USE THEREOF AS INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR KINASES | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-02-12 | — | — | WO | claimed |
| WO-2004013091-A2 | 4-ANILIDO SUBSTITUTED QUINAZOLINES AND USE THEREOF AS INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR KINASES | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-02-12 | — | — | WO | disclosed |