Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | NPY1R | P25929 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6664810 | 0.92 | SLC6A4 (0.39) | DRD2DRD4DRD3MCHR1S1PR5 | |
| SCHEMBL6710663 | 0.90 | DRD2 (0.40) | DRD2DRD4DRD3MCHR1S1PR5 | |
| SCHEMBL5899921 | 0.90 | S1PR5 (0.41) | DRD2DRD4DRD3MCHR1S1PR5 | |
| Hydrochloric Acid SCHEMBL5899863 | 0.89 | S1PR5 (0.41) | DRD2DRD4DRD3MCHR1S1PR5 | |
| SCHEMBL5937192 | 0.88 | DRD2 (0.42) | DRD2DRD4DRD3MCHR1S1PR5 | |
| SCHEMBL6790396 | 0.88 | DRD2 (0.39) | DRD2DRD4DRD3MCHR1S1PR5 | |
| SCHEMBL5899905 | 0.87 | S1PR5 (0.46) | DRD2MCHR1S1PR5NPY1RSMN1; SMN2 | |
| SCHEMBL5899852 | 0.86 | S1PR5 (0.41) | DRD2DRD4DRD3MCHR1S1PR5 | |
| SCHEMBL6661716 | 0.84 | DRD2 (0.39) | DRD2DRD4DRD3MCHR1S1PR5 | |
| SCHEMBL6660507 | 0.84 | DRD2 (0.39) | DRD2DRD4DRD3MCHR1S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004006923-A1 | ARYL PIPERIDINE DERIVATIVES AS INDUCERS OF LDL-RECEPTOR EXPRESSION FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA | GLAXO GROUP LIMITED (GB) | 2004-01-22 | — | — | WO | claimed |
| WO-2004007493-A1 | ARYL PIPERIDINE DERIVATIVES AS INDUCERS OF LDL-RECEPTOR EXPRESSION FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA | GLAXO GROUP LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |
| WO-2004006923-A1 | ARYL PIPERIDINE DERIVATIVES AS INDUCERS OF LDL-RECEPTOR EXPRESSION FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA | GLAXO GROUP LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |