SCHEMBL6664396

SCHEMBL6664396

Clc1cccnc1C(Cl)Cl

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.38
TDP1 Q9NUW8 2/20 0.37
S1PR3 Q99500 2/20 0.36
S1PR1 P21453 1/20 0.36
LMNA P02545 3/20 0.35
KDM4E B2RXH2 2/20 0.35
HSP90AA1 P07900 2/20 0.35
MAPT P10636 2/20 0.35
CCR1 P32246 1/20 0.35
CCR8 P51685 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
BRD4 O60885 1/20 0.35
METAP2 P50579 1/20 0.35
METAP1 P53582 1/20 0.35
DPP4 P27487 1/20 0.35
PDE3B Q13370 1/20 0.35
PDE3A Q14432 1/20 0.35
TSHR P16473 1/20 0.35
CYP2D6 P10635 1/20 0.35
HRH1 P35367 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28205012 0.82 CYP2D6 (0.39) CYP2C19TDP1S1PR3S1PR1LMNA
SCHEMBL1690313 0.81 CYP2D6 (0.40) CYP2C19TDP1S1PR3S1PR1LMNA
SCHEMBL29496307 0.79 S1PR3 (0.38) CYP2C19TDP1S1PR3S1PR1LMNA
SCHEMBL14034132 0.79 S1PR3 (0.38) CYP2C19TDP1S1PR3S1PR1LMNA
SCHEMBL9370551 0.79 S1PR3 (0.38) CYP2C19TDP1S1PR3S1PR1LMNA
SCHEMBL30824549 0.77 CYP2D6 (0.45) CYP2C19S1PR3S1PR1LMNADPP4
SCHEMBL21071356 0.77 CYP2D6 (0.45) CYP2C19S1PR3S1PR1LMNADPP4
SCHEMBL22495173 0.77 CYP2D6 (0.45) CYP2C19S1PR3S1PR1LMNADPP4
SCHEMBL27147342 0.77 CYP2D6 (0.45) CYP2C19S1PR3S1PR1LMNADPP4
SCHEMBL10643301 0.76 PDE3B (0.35) CYP2C19TDP1LMNAKDM4EHSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110195239-B Method for preparing aldehyde and acid by electrochemical dechlorination of polychlorinated methyl pyridine derivative 浙江工业大学 2020-08-14 CN disclosed
CN-110195239-A A kind of method that more chloromethyl pyridine derivative electrochemistry dechlorinations prepare aldehyde, acid 浙江工业大学 2019-09-03 CN disclosed
CN-109694346-A The method that 2- picoline liquid phase Light chlorimation prepares N-serve 浙江埃森化学有限公司 2019-04-30 CN disclosed
EP-0970052-B1 METHOD FOR PRODUCING 5-AMINOMETHYL-2-CHLOROPYRIDINES BAYER CROPSCIENCE AG (DE) 2004-08-11 EP disclosed
US-6150528-A Method for producing 5-aminomethyl-2-chloropyridines BAYER AKTIENGESELLSCHAFT (DE) 2000-11-21 US disclosed
EP-0970052-A1 METHOD FOR PRODUCING 5-AMINOMETHYL-2-CHLOROPYRIDINES BAYER AG (DE) 2000-01-12 EP disclosed
WO-1998041504-A1 METHOD FOR PRODUCING 5-AMINOMETHYL-2-CHLOROPYRIDINES BAYER AKTIENGESELLSCHAFT (DE) 1998-09-24 WO disclosed