Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 3/20 | 0.35 |
| ▸ | CCR8 | P51685 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.30 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4722076 | 0.79 | GSK3B (0.43) | L3MBTL1LMNACYP3A4MAPTAPEX1 | |
| SCHEMBL4720464 | 0.75 | GSK3B (0.37) | CCR1CCR8L3MBTL1LMNACYP3A4 | |
| SCHEMBL23024873 | 0.69 | L3MBTL1 (0.43) | L3MBTL1CYP3A4MAPTMAPK1ALDH1A1 | |
| SCHEMBL26021801 | 0.69 | TRPM4 (0.50) | L3MBTL1LMNACYP3A4MAPTAPEX1 | |
| SCHEMBL31005182 | 0.68 | PDE5A (0.44) | L3MBTL1LMNAMAPTMAPK1ALDH1A1 | |
| SCHEMBL8096509 | 0.68 | CYP1A2 (0.49) | CYP3A4MAPTMAPK1ALDH1A1ESR1 | |
| SCHEMBL28903937 | 0.68 | CYP1A2 (0.56) | L3MBTL1LMNAMAPTALDH1A1ESR1 | |
| SCHEMBL21926318 | 0.68 | KMT2A (0.60) | MAPTMAPK1ALDH1A1CYP2A6CYP11B1 | |
| SCHEMBL30866407 | 0.66 | MAPT (0.45) | L3MBTL1LMNAMAPTMAPK1ALDH1A1 | |
| SCHEMBL30901487 | 0.65 | MEN1 (0.56) | MAPTMAPK1ALDH1A1CYP11B1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427421-A1 | 2,4-DISUBSTITUTED PYRIMIDINYL DERIVATIVES FOR USE AS ANTICANCER AGENTS | Amgen Inc. (US) | 2004-06-16 | — | — | EP | disclosed |
| WO-2003018021-A1 | 2,4-DISUBSTITUTED PYRIMIDINYL DERIVATIVES FOR USE AS ANTICANCER AGENTS | AMGEN INC. (US) | 2003-03-06 | — | — | WO | disclosed |