Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.74 |
| ▸ | ABL1 | P00519 | 3/20 | 0.56 |
| ▸ | RAF1 | P04049 | 3/20 | 0.56 |
| ▸ | LYN | P07948 | 3/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.56 |
| ▸ | BRAF | P15056 | 2/20 | 0.56 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.56 |
| ▸ | EPHA3 | P29320 | 2/20 | 0.56 |
| ▸ | AKT1 | P31749 | 1/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.49 |
| ▸ | SRC | P12931 | 5/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | GSK3A | P49840 | 4/20 | 0.44 |
| ▸ | TNF | P01375 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 3/20 | 0.42 |
| ▸ | CIT | O14578 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6879984 | 0.94 | MAPK14 (0.64) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL6637374 | 0.92 | MAPK14 (0.63) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4091692 | 0.86 | MAPK14 (0.84) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4092378 | 0.85 | MAPK14 (1.00) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL6636953 | 0.83 | MAPK14 (0.54) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL6872586 | 0.82 | MAPK14 (0.71) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL6637183 | 0.82 | MAPK14 (0.57) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL6811590 | 0.81 | MAPK14 (0.71) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL6637081 | 0.81 | MAPK14 (0.56) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL7687833 | 0.80 | MAPK14 (0.74) | MAPK14ABL1RAF1LYNMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825184-B2 | FOR USE AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2004-11-30 | — | — | US | claimed |
| EP-1438048-A1 | 1,4-DISUBSTITUTED BENZO-FUSED UREA COMPOUNDS AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2004-07-21 | — | — | EP | claimed |
| WO-2003032989-A1 | 1,4-DISUBSTITUTED BENZO-FUSED UREA COMPOUNDS AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2003-04-24 | — | — | WO | claimed |
| US-6825184-B2 | FOR USE AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2004-11-30 | — | — | US | disclosed |