Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 6/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | WHR1 | P49842 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6181492 | 0.80 | EGFR (0.72) | PDGFRBPDGFRAEGFRKDRKIT | |
| SCHEMBL30957576 | 0.79 | CDK7 (0.54) | PDGFRBPDGFRAEGFRKDRKIT | |
| SCHEMBL17542563 | 0.79 | CDK7 (0.54) | PDGFRBPDGFRAEGFRKDRKIT | |
| SCHEMBL4409462 | 0.77 | WHR1 (0.47) | EGFRKDRKITWHR1MEN1 | |
| SCHEMBL6667122 | 0.77 | SMN1; SMN2 (0.53) | EGFRKDRWHR1MEN1KMT2A | |
| SCHEMBL27117037 | 0.76 | WHR1 (0.71) | PDGFRBPDGFRAEGFRKDRWHR1 | |
| SCHEMBL20267012 | 0.74 | HTT (0.57) | ELANEMEN1KMT2ALMNACYP1A2 | |
| SCHEMBL8176662 | 0.72 | KDM4E (0.73) | PDGFRBPDGFRAKDRKITFLT4 | |
| SCHEMBL1941112 | 0.72 | WHR1 (0.60) | PDGFRBPDGFRAEGFRKDRWHR1 | |
| SCHEMBL8172242 | 0.72 | PDGFRB (1.00) | PDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004013091-A2 | 4-ANILIDO SUBSTITUTED QUINAZOLINES AND USE THEREOF AS INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR KINASES | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-02-12 | — | — | WO | claimed |
| WO-2004013091-A2 | 4-ANILIDO SUBSTITUTED QUINAZOLINES AND USE THEREOF AS INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR KINASES | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-02-12 | — | — | WO | disclosed |