Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CCND3 | P30281 | 1/20 | 0.46 |
| ▸ | WHR1 | P49842 | 1/20 | 0.44 |
| ▸ | ITK | Q08881 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27117037 | 0.77 | WHR1 (0.71) | SMN1; SMN2KDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL6667126 | 0.77 | PDGFRB (0.56) | SMN1; SMN2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL14765132 | 0.75 | RAB9A (0.56) | SMN1; SMN2KDM4EMAPTRAB9AALDH1A1 | |
| SCHEMBL13700949 | 0.73 | MEN1 (0.60) | SMN1; SMN2KDM4EMAPTRAB9AALDH1A1 | |
| SCHEMBL1941112 | 0.73 | WHR1 (0.60) | SMN1; SMN2KDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL4409462 | 0.73 | WHR1 (0.47) | SMN1; SMN2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL27117143 | 0.70 | ALDH1A1 (0.57) | SMN1; SMN2KDM4EMAPTALDH1A1KDR | |
| 2-(2'-Methoxyphenyl)-1H-Indole SCHEMBL5634916 | 0.70 | KDM4E (1.00) | SMN1; SMN2KDM4EMAPTRAB9AALDH1A1 | |
| 2-(2'-Methoxyphenyl)-1H-Indole SCHEMBL31053096 | 0.70 | KDM4E (1.00) | SMN1; SMN2KDM4EMAPTRAB9AALDH1A1 | |
| SCHEMBL27117202 | 0.70 | WHR1 (0.53) | SMN1; SMN2KDM4EMAPTALDH1A1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004013091-A2 | 4-ANILIDO SUBSTITUTED QUINAZOLINES AND USE THEREOF AS INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR KINASES | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-02-12 | — | — | WO | claimed |
| WO-2004013091-A2 | 4-ANILIDO SUBSTITUTED QUINAZOLINES AND USE THEREOF AS INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR KINASES | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-02-12 | — | — | WO | disclosed |