Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.77 |
| ▸ | FLT1 | P17948 | 7/20 | 0.77 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.77 |
| ▸ | FLT4 | P35916 | 3/20 | 0.77 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.77 |
| ▸ | RET | P07949 | 5/20 | 0.75 |
| ▸ | KIF5B | P33176 | 5/20 | 0.75 |
| ▸ | EPHA2 | P29317 | 4/20 | 0.71 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.71 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.71 |
| ▸ | EGFR | P00533 | 7/20 | 0.69 |
| ▸ | SRC | P12931 | 1/20 | 0.69 |
| ▸ | AURKA | O14965 | 1/20 | 0.66 |
| ▸ | INSR | P06213 | 1/20 | 0.66 |
| ▸ | FBP1 | P09467 | 1/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.66 |
| ▸ | CLK1 | P49759 | 1/20 | 0.66 |
| ▸ | TEK | Q02763 | 1/20 | 0.66 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20355392 | 0.91 | KDR (0.64) | KDRFLT1FGFR1FLT4EPHB2 | |
| SCHEMBL17179538 | 0.91 | EGFR (0.70) | KDRFLT1FGFR1FLT4EPHB2 | |
| SCHEMBL159404 | 0.91 | KDR (0.64) | KDRFLT1FGFR1FLT4EPHB2 | |
| SCHEMBL17179601 | 0.91 | EGFR (0.68) | KDRFLT1FGFR1FLT4EPHB2 | |
| Hydrochloric Acid SCHEMBL28028749 | 0.90 | KDR (0.63) | KDRFLT1FGFR1FLT4EPHB2 | |
| SCHEMBL17967487 | 0.88 | EGFR (0.65) | KDRFLT1FGFR1FLT4EPHB2 | |
| SCHEMBL18012088 | 0.88 | KDR (0.66) | KDRFLT1FGFR1FLT4EPHB2 | |
| SCHEMBL3392679 | 0.88 | KDR (0.69) | KDRFLT1FGFR1FLT4EPHB2 | |
| SCHEMBL18012077 | 0.88 | KDR (0.66) | KDRFLT1FGFR1FLT4EPHB2 | |
| SCHEMBL3012896 | 0.87 | KDR (1.00) | KDRFLT1FGFR1FLT4EPHB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004013091-A2 | 4-ANILIDO SUBSTITUTED QUINAZOLINES AND USE THEREOF AS INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR KINASES | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-02-12 | — | — | WO | disclosed |