Sugi Predict

Sugi Predict / Compounds / Chlorobenzene

Chlorobenzene

Chlorobenzene

SCHEMBL6669403

Clc1ccccc1.O=S(=O)(O)Cl

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 3/20 0.65
▸ TDP1 Q9NUW8 2/20 0.50
▸ ALDH1A1 P00352 2/20 0.50
▸ HSD17B10 Q99714 1/20 0.50
▸ SMN1; SMN2 Q16637 1/20 0.50
▸ CES2 O00748 1/20 0.48
▸ CES1 P23141 1/20 0.48
▸ CYP1A2 P05177 1/20 0.46
▸ HSD11B1 P28845 2/20 0.44
▸ FLT1 P17948 1/20 0.44
▸ FLT4 P35916 1/20 0.44
▸ KDR P35968 1/20 0.44
▸ L3MBTL1 Q9Y468 1/20 0.44
▸ MEN1 O00255 1/20 0.44
▸ KMT2A Q03164 1/20 0.44
▸ CYP3A4 P08684 1/20 0.43
▸ MAPK1 P28482 1/20 0.43
▸ ORAI1 Q96D31 1/20 0.42
▸ ORAI2 Q96SN7 1/20 0.42
▸ ORAI3 Q9BRQ5 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Chlorobenzene SCHEMBL231594 0.91 TSHR (0.69) TSHRTDP1ALDH1A1HSD17B10SMN1; SMN2
Chlorobenzene SCHEMBL7223075 0.91 TSHR (0.69) TSHRTDP1ALDH1A1HSD17B10SMN1; SMN2
Chlorobenzene SCHEMBL27597095 0.88 TSHR (0.65) TSHRTDP1ALDH1A1HSD17B10SMN1; SMN2
SCHEMBL9836272 0.88 CYP1A2 (0.68) TSHRCES2CES1CYP1A2FLT1
1,4-Dichlorobenzene SCHEMBL9711108 0.88 ALDH1A1 (0.55) TSHRALDH1A1CES2CES1MEN1
Chlorobenzene SCHEMBL7454781 0.86 TSHR (0.61) TSHRTDP1ALDH1A1HSD17B10SMN1; SMN2
Chlorobenzene SCHEMBL27624746 0.86 TSHR (0.61) TSHRTDP1ALDH1A1HSD17B10SMN1; SMN2
Chlorobenzene SCHEMBL27465656 0.86 TSHR (0.61) TSHRSMN1; SMN2CES2CES1CYP1A2
Chlorobenzene SCHEMBL28240547 0.83 TSHR (0.58) TSHRTDP1ALDH1A1HSD17B10SMN1; SMN2
Chlorobenzene SCHEMBL31175844 0.82 TSHR (0.65) TSHRCES2CES1CYP1A2ORAI1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4666637-A Process for producing chlorobenzene sulfochloride NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1987-05-19 — — US claimed
EP-0115328-B1 PROCESS FOR THE PREPARATION OF 4-CHLORO-PHENYL-SULPHONYL-COMPOUNDS HOECHST AKTIENGESELLSCHAFT (DE) 1986-02-19 — — EP claimed
EP-0115328-A1 Process for the preparation of 4-chloro-phenyl-sulphonyl-compounds HOECHST AKTIENGESELLSCHAFT (DE) 1984-08-08 — — EP claimed
JP-3077879-A — — None — — JP disclosed
EP-3055299-B1 PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS ACETYLON PHARMACEUTICALS INC (US) 2021-01-06 — — EP disclosed
US-20160279128-A1 PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS ACETYLON PHARMACEUTICALS, INC. 2016-09-29 — — US disclosed
EP-3055299-A1 PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS Acetylon Pharmaceuticals, Inc. (US) 2016-08-17 — — EP disclosed
US-9278963-B2 Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors ACETYLON PHARMACEUTICALS, INC. (US) 2016-03-08 — — US disclosed
US-20150105384-A1 PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS ACETYLON PHARMACEUTICALS, INC. (US) 2015-04-16 — — US disclosed
WO-2015054474-A1 PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS ACETYLON PHARMACEUTICALS, INC. (US) 2015-04-16 — — WO disclosed
EP-1456179-A1 DEUTERATED SUBSTITUTED PYRAZOLYLBENZYLSULFONAMIDES AND MEDICAMENTS COMPRISING SAID COMPOUNDS Turicum Drug Development AG (CH) 2004-09-15 — — EP disclosed
EP-0004011-A1 Phenoxyalkylcarboxylic-acid derivatives, process for their preparation and medicaments containing them Roche Diagnostics GmbH (DE) 1979-09-19 — — EP disclosed
EP-0002755-A2 Process for preparing arylthiols and the compounds thus obtained CIBA-GEIGY AG (CH) 1979-07-11 — — EP disclosed
US-4067741-A Hardening photographic layers containing silver halide with a 1-sulphonyl-4-amino-pyridinium salt AGFA-GEVAERT, A.G. (DT) 1978-01-10 — — US disclosed
US-4057419-A 2,4-Bis-(trifluoromethyl)-6-nitrophenol compounds and herbicidal compositions BAYER AKTIENGESELLSCHAFT (DT) 1977-11-08 — — US disclosed
US-3987047-A ANORETICS BOEHRINGER INGELHEIM GMBH (DT) 1976-10-19 — — US disclosed
US-3966703-A Asymmetrical frisazo dyestuffs derived from diazotized 2,7-diamino-carbazole BAYER AKTIENGESELLSCHAFT (DT) 1976-06-29 — — US disclosed
US-3944502-A Process for preparing microcapsules containing hydrophobic oil drops FUJI PHOTO FILM CO., LTD. (JA) 1976-03-16 — — US disclosed
US-3943180-A 2,4-Bis-(trifluoromethyl)-6-nitrophenol compounds and herbicidal compositions BAYER AKTIENGESELLSCHAFT (DT) 1976-03-09 — — US disclosed
US-3932419-A QUINOLINE DYES BAYER AKTIENGESELLSCHAFT (DT) 1976-01-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160279128-A1 PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS HDAC1, HDAC11, HDAC2 TSHR 3969/4885TDP1 508/4885ALDH1A1 667/4885
US-20150105384-A1 PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS HDAC1, HDAC11, HDAC2 TSHR 3969/4885TDP1 508/4885ALDH1A1 667/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.