Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TOP1 | P11387 | 5/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6649151 | 0.91 | KCNH2 (0.59) | KCNH2TOP1 | |
| SCHEMBL6372572 | 0.89 | KCNH2 (0.44) | KCNH2POLBKDM4EPRKD3ALDH1A1 | |
| SCHEMBL6379111 | 0.88 | KCNH2 (0.43) | KCNH2POLBKDM4EPRKD3ALDH1A1 | |
| SCHEMBL6669749 | 0.85 | TOP1 (0.46) | KCNH2POLBKDM4EPRKD3ALDH1A1 | |
| SCHEMBL6671608 | 0.85 | TOP1 (0.46) | KCNH2POLBKDM4EPRKD3ALDH1A1 | |
| SCHEMBL6669733 | 0.85 | KCNH2 (0.53) | KCNH2POLBKDM4EPRKD3ALDH1A1 | |
| SCHEMBL5465077 | 0.85 | KCNH2 (0.45) | KCNH2POLBKDM4EPRKD3ALDH1A1 | |
| SCHEMBL7093474 | 0.85 | KCNH2 (0.51) | KCNH2POLBKDM4EPRKD3ALDH1A1 | |
| SCHEMBL6377876 | 0.84 | KCNH2 (0.40) | KCNH2POLBKDM4EPRKD3ALDH1A1 | |
| SCHEMBL6370780 | 0.84 | KCNH2 (0.46) | KCNH2POLBKDM4EPRKD3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401830-A2 | QUINAZOLINEDIONES AS ANTIBACTERIAL AGENTS | Warner-Lambert Company LLC (US) | 2004-03-31 | — | — | EP | claimed |
| WO-2002102793-A2 | QUINAZOLINEDIONES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY LLC (US) | 2002-12-27 | — | — | WO | claimed |