Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23852691 | 0.80 | KDM4E (0.49) | KDM4ETSHRHPGDHSD17B10KMT2A | |
| SCHEMBL5414519 | 0.80 | JAK2 (0.54) | PRKCQUTS2RJAK2JAK1NSD2 | |
| SCHEMBL7554920 | 0.78 | KDM4E (0.54) | KDM4ETSHRHPGDHSD17B10KMT2A | |
| SCHEMBL30804592 | 0.74 | KDM4E (0.55) | KDM4ETSHRHPGDHSD17B10KMT2A | |
| SCHEMBL395135 | 0.74 | KDM4E (0.55) | KDM4ETSHRHPGDHSD17B10KMT2A | |
| SCHEMBL30804597 | 0.74 | KDM4E (0.55) | KDM4ETSHRHPGDHSD17B10KMT2A | |
| SCHEMBL25867667 | 0.73 | JAK2 (0.38) | PRKCQCHUKJAK2JAK1 | |
| SCHEMBL15486368 | 0.73 | KDM4E (0.61) | KDM4ETSHRHPGDHSD17B10KMT2A | |
| SCHEMBL6206235 | 0.73 | TSHR (0.61) | KDM4ETSHRHPGDHSD17B10KMT2A | |
| SCHEMBL20587134 | 0.72 | LIPC (0.47) | KDM4EHPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1390350-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2004-02-25 | — | — | EP | disclosed |
| WO-2002085866-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2002-10-31 | — | — | WO | disclosed |