Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 3/20 | 0.62 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.60 |
| ▸ | PDE5A | O76074 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | RAD52 | P43351 | 1/20 | 0.52 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.52 |
| ▸ | ACP1 | P24666 | 2/20 | 0.51 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6670648 | 0.94 | SLC2A1 (0.80) | SLC2A1POLBTLR9PDE5AMEN1 | |
| SCHEMBL3980449 | 0.88 | SLC2A1 (0.78) | SLC2A1POLBMEN1KMT2ARAD52 | |
| SCHEMBL1085522 | 0.85 | POLB (0.83) | SLC2A1POLBTLR9PDE5AMEN1 | |
| SCHEMBL3980413 | 0.83 | SLC2A1 (0.62) | SLC2A1POLBTLR9MEN1KMT2A | |
| SCHEMBL3973291 | 0.83 | SLC2A1 (0.64) | SLC2A1POLBMEN1KMT2ARAD52 | |
| SCHEMBL3972870 | 0.83 | SLC2A1 (0.70) | SLC2A1POLBMEN1KMT2ARAD52 | |
| SCHEMBL3974647 | 0.83 | FLT3 (0.70) | SLC2A1POLBMEN1KMT2ARAD52 | |
| SCHEMBL3972522 | 0.82 | SLC2A1 (0.63) | SLC2A1POLBMEN1KMT2AHMOX1 | |
| SCHEMBL3971151 | 0.82 | CCR4 (0.68) | SLC2A1POLBMEN1KMT2AKDM4E | |
| SCHEMBL3976619 | 0.81 | SLC2A1 (0.64) | SLC2A1POLBMEN1KMT2ARAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004030672-A1 | USE OF 4 AMINO-QUINAZOLINES AS ANTI CANCER AGENTS | MERCK PATENT GMBH (DE) | 2004-04-15 | — | — | WO | disclosed |
| EP-1318984-A1 | 4-AMINO-QUINAZOLINES | MERCK PATENT GmbH (DE) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024667-A1 | 4-AMINO-QUINAZOLINES | MERCK PATENT GMBH (DE) | 2002-03-28 | — | — | WO | disclosed |