SCHEMBL6671636

SCHEMBL6671636

C#Cc1ccc(C2=C(c3ccccc3)C(=O)C(c3ccccc3)=C2c2ccccc2)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 3/20 0.42
ESR2 Q92731 3/20 0.42
CYP2C9 P11712 2/20 0.40
PDE4B Q07343 1/20 0.39
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA4 P22748 1/20 0.39
CA9 Q16790 1/20 0.39
CA14 Q9ULX7 1/20 0.39
FGFR1 P11362 2/20 0.39
FGFR2 P21802 2/20 0.39
FGFR4 P22455 2/20 0.39
FGFR3 P22607 2/20 0.39
CDC25A P30304 1/20 0.38
CDC25B P30305 1/20 0.38
MEN1 O00255 1/20 0.37
APAF1 O14727 1/20 0.37
NPC1 O15118 1/20 0.37
LMNA P02545 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13586775 0.98 ESR1 (0.41) ESR1ESR2CYP2C9PDE4BCA12
SCHEMBL13586753 0.98 ESR1 (0.41) ESR1ESR2CYP2C9PDE4BCA12
SCHEMBL13586766 0.98 ESR1 (0.41) ESR1ESR2CYP2C9PDE4BCA12
SCHEMBL13581864 0.93 APP (0.41) ESR1ESR2CYP2C9PDE4BCA12
SCHEMBL13586754 0.91 ESR1 (0.41) ESR1ESR2CYP2C9PDE4BCA12
SCHEMBL13586778 0.91 MEN1 (0.43) ESR1ESR2CYP2C9PDE4BCA12
SCHEMBL13582001 0.91 APP (0.43) ESR1ESR2CYP2C9CA12CA1
SCHEMBL13582396 0.91 APP (0.43) ESR1ESR2CYP2C9CA12CA1
SCHEMBL23380165 0.90 GSTP1 (0.42) ESR1ESR2CYP2C9PDE4BCA1
SCHEMBL13586795 0.88 GSTP1 (0.41) ESR1ESR2PDE4BCA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1170279-B1 Polyphenylene oligomers and polymers DOW GLOBAL TECHNOLOGIES INC (US) 2004-09-29 EP claimed
EP-1170279-A1 Polyphenylene oligomers and polymers THE DOW CHEMICAL COMPANY (US) 2002-01-09 EP claimed
EP-0889920-A1 POLYPHENYLENE OLIGOMERS AND POLYMERS THE DOW CHEMICAL COMPANY (US) 1999-01-13 EP claimed
WO-1998011149-A1 POLYPHENYLENE OLIGOMERS AND POLYMERS THE DOW CHEMICAL COMPANY (US) 1998-03-19 WO claimed
EP-1170279-B1 Polyphenylene oligomers and polymers DOW GLOBAL TECHNOLOGIES INC (US) 2004-09-29 EP disclosed
EP-0889920-B1 POLYPHENYLENE OLIGOMERS AND POLYMERS DOW CHEMICAL CO (US) 2002-02-13 EP disclosed
EP-1170279-A1 Polyphenylene oligomers and polymers THE DOW CHEMICAL COMPANY (US) 2002-01-09 EP disclosed
US-6288188-B1 ACETYLENIC POLYMERS; INTEGRATED CIRCUITS, DIELECTRICS, MICROELECTRONICS THE DOW CHEMICAL COMPANY 2001-09-11 US disclosed
US-5965679-A BASED A BISCYCLOPENTADIENONE AND AN AROMATIC DIACETYLENE; CURING; LOW DIELECTRIC; INTEGRATED CIRCUITS; MICROELECTRONICS; PRINTED CIRCUITS THE DOW CHEMICAL COMPANY (US) 1999-10-12 US disclosed
EP-0889920-A1 POLYPHENYLENE OLIGOMERS AND POLYMERS THE DOW CHEMICAL COMPANY (US) 1999-01-13 EP disclosed
WO-1998011149-A1 POLYPHENYLENE OLIGOMERS AND POLYMERS THE DOW CHEMICAL COMPANY (US) 1998-03-19 WO disclosed