Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.35 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 3/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | NEK9 | Q8TD19 | 1/20 | 0.34 |
| ▸ | NEK6 | Q9HC98 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8501657 | 0.89 | PDE4A (0.37) | KDRENPP1BRD4EGFRERBB2 | |
| Hydrochloric Acid SCHEMBL8501633 | 0.88 | PDE4A (0.37) | KDRENPP1BRD4EGFRERBB2 | |
| SCHEMBL5272824 | 0.87 | KDR (0.46) | KDRATMTYK2NEK9NEK6 | |
| Hydrochloric Acid SCHEMBL8187414 | 0.85 | KDR (0.34) | KDRENPP1PDE1BMAPK7 | |
| SCHEMBL5500150 | 0.82 | ATM (0.49) | KDREGFRATM | |
| SCHEMBL6588693 | 0.82 | CHEK1 (0.42) | KDREGFRMAPK7 | |
| SCHEMBL5272713 | 0.80 | EGFR (0.48) | KDREGFRERBB2 | |
| SCHEMBL5498754 | 0.79 | SRC (0.53) | KDREGFRATM | |
| SCHEMBL5276106 | 0.79 | SRC (0.53) | KDREGFRATM | |
| Acetic Acid SCHEMBL4677365 | 0.79 | EGFR (0.36) | KDRENPP1EGFRMAPK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458395-A1 | NEW USE | AstraZeneca AB (SE) | 2004-09-22 | — | — | EP | claimed |
| WO-2003053444-A1 | NEW USE | ASTRAZENECA AB (SE) | 2003-07-03 | — | — | WO | claimed |
| EP-1005470-A1 | OXINDOLYLQUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 2000-06-07 | — | — | EP | claimed |
| WO-1999010349-A1 | OXINDOLYLQUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 1999-03-04 | — | — | WO | claimed |
| EP-1458395-A1 | NEW USE | AstraZeneca AB (SE) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003053444-A1 | NEW USE | ASTRAZENECA AB (SE) | 2003-07-03 | — | — | WO | disclosed |
| EP-1005470-A1 | OXINDOLYLQUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 2000-06-07 | — | — | EP | disclosed |
| WO-1999010349-A1 | OXINDOLYLQUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 1999-03-04 | — | — | WO | disclosed |