Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.31 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.30 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.30 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.30 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.30 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6672372 | 0.87 | TUBB1 (0.38) | TUBB1SMN1; SMN2ALDH1A1GAAMAPT | |
| SCHEMBL6674339 | 0.87 | TUBB1 (0.38) | TUBB1 | |
| SCHEMBL6671200 | 0.86 | TUBB1 (0.37) | TUBB1SMN1; SMN2ALDH1A1GAAMAPT | |
| SCHEMBL6258931 | 0.83 | TUBB1 (0.34) | TUBB1 | |
| SCHEMBL6671858 | 0.81 | TUBB1 (0.67) | TUBB1SMN1; SMN2ALDH1A1GAATDP1 | |
| SCHEMBL6674364 | 0.81 | TUBB1 (0.67) | TUBB1SMN1; SMN2ALDH1A1GAATDP1 | |
| SCHEMBL6674391 | 0.76 | TUBB1 (0.47) | TUBB1 | |
| SCHEMBL6805842 | 0.75 | TUBB1 (0.40) | TUBB1 | |
| SCHEMBL6670372 | 0.74 | TUBB1 (0.67) | TUBB1SMN1; SMN2GAANPSR1KMT2A | |
| SCHEMBL20732296 | 0.74 | TUBB1 (0.67) | TUBB1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004026293-A2 | HEMIASTERLIN DERIVATIVES FOR TREATING RESISTANT TUMORS | WYETH HOLDINGS CORPORATION (US) | 2004-04-01 | — | — | WO | disclosed |