Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 12/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.32 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.32 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL667187 | 1.00 | MME (0.37) | MMEAGTR1AGTR2PTGER1MDM2 | |
| SCHEMBL661038 | 0.92 | MME (0.35) | MMEAGTR1AGTR2 | |
| SCHEMBL653065 | 0.92 | MME (0.35) | MMEAGTR1AGTR2 | |
| SCHEMBL994219 | 0.92 | MME (0.35) | MMEAGTR1AGTR2 | |
| SCHEMBL1083144 | 0.91 | MME (0.41) | MME | |
| SCHEMBL653732 | 0.91 | MME (0.41) | MME | |
| SCHEMBL653055 | 0.89 | MME (0.38) | MMEAGTR1AGTR2 | |
| SCHEMBL653056 | 0.89 | MME (0.38) | MMEAGTR1AGTR2 | |
| SCHEMBL1074203 | 0.89 | AGTR1 (0.34) | MMEAGTR1AGTR2 | |
| SCHEMBL656367 | 0.89 | AGTR1 (0.34) | MMEAGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451782-A1 | DUAL-ACTING PYRAZOLE ANTIHYPERTENSIVE AGENTS | Theravance, Inc. (US) | 2012-05-16 | — | — | EP | disclosed |
| US-8119634-B2 | Dual-acting pyrazole antihypertensive agents | THERAVANCE, INC. (US) | 2012-02-21 | — | — | US | disclosed |
| WO-2011005674-A1 | DUAL-ACTING PYRAZOLE ANTIHYPERTENSIVE AGENTS | THERAVANCE, INC. (US) | 2011-01-13 | — | — | WO | disclosed |