Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TOP2A | P11388 | 4/20 | 0.45 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4373748 | 0.87 | KCNH2 (0.57) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL4369255 | 0.87 | KCNH2 (0.67) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL6371482 | 0.85 | KCNH2 (0.59) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL4371487 | 0.83 | KCNH2 (0.69) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL4365337 | 0.79 | KCNH2 (0.58) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL4366666 | 0.79 | KCNH2 (0.65) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL4364180 | 0.78 | KCNH2 (0.63) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL5094612 | 0.78 | KCNH2 (0.68) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL7225205 | 0.78 | LMNA (0.79) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL2365463 | 0.78 | KCNH2 (0.68) | KCNH2ALDH1A1POLBOPRM1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392677-A2 | CHIRAL BROAD-SPECTRUM ANTIBACTERIAL 7-SUBSTITUTED PIPERIDINO-QUINOLONE CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND COMPOSITIONS | Wockhardt Limited (IN) | 2004-03-03 | — | — | EP | claimed |
| WO-2002085886-A2 | CHIRAL, BROAD-SPECTRUM ANTIBACTERIAL 7-SUBSTITUTED PIPERIDINO-QUINOLONE CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND COMPOSITIONS | WOCKHARDT LIMITED (IN) | 2002-10-31 | — | — | WO | claimed |