Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 16/20 | 0.73 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ACACB | O00763 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | CCR2 | P41597 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202705 | 0.85 | HRH3 (1.00) | HRH3GAASMN1; SMN2 | |
| SCHEMBL5202473 | 0.79 | HRH3 (1.00) | HRH3GAASMN1; SMN2 | |
| SCHEMBL5203226 | 0.78 | HRH3 (0.73) | HRH3GAASMN1; SMN2 | |
| SCHEMBL2564105 | 0.78 | ACACB (0.52) | HRH3GAASMN1; SMN2ACACBROCK2 | |
| SCHEMBL5204224 | 0.77 | HRH3 (1.00) | HRH3 | |
| SCHEMBL6674200 | 0.77 | HRH3 (1.00) | HRH3 | |
| SCHEMBL5203493 | 0.77 | HRH3 (1.00) | HRH3GAASMN1; SMN2 | |
| SCHEMBL5207784 | 0.77 | HRH3 (1.00) | HRH3 | |
| SCHEMBL10610498 | 0.77 | ROCK1 (0.55) | HRH3GAASMN1; SMN2ROCK2CCR2 | |
| SCHEMBL7846425 | 0.77 | SIGMAR1 (0.65) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004035544-A1 | BENZO[D]AZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2004-04-29 | — | — | WO | disclosed |