Benzenesulfonamide

Benzenesulfonamide

SCHEMBL6672452

NS(=O)(=O)c1ccccc1.O=S(=O)(O)c1cccc2c(I)cccc12

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TTR P02766 1/20 0.50
CA1 P00915 9/20 0.48
CA2 P00918 9/20 0.48
CA9 Q16790 8/20 0.48
CA12 O43570 7/20 0.48
CA3 P07451 1/20 0.48
CA4 P22748 1/20 0.48
CA6 P23280 1/20 0.48
CA5A P35218 1/20 0.48
CA7 P43166 1/20 0.48
PLA2G7 Q13093 1/20 0.48
CA13 Q8N1Q1 1/20 0.48
CA14 Q9ULX7 1/20 0.48
CA5B Q9Y2D0 1/20 0.48
CDK2 P24941 1/20 0.44
CYP1A2 P05177 3/20 0.43
AURKA O14965 1/20 0.41
AURKB Q96GD4 1/20 0.41
ATIC P31939 1/20 0.40
TSHR P16473 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5284994 0.85 TTR (0.60) TTRCDK2CYP1A2AURKAAURKB
SCHEMBL9468252 0.80 TTR (0.48) TTRCYP1A2AURKAAURKBTSHR
SCHEMBL28787703 0.78 CDK2 (0.62) TTRCA1CA2CA9CA12
SCHEMBL15151195 0.78 TTR (0.50) TTRCYP1A2AURKAAURKBTSHR
SCHEMBL9468242 0.77 TTR (0.48) TTRCYP1A2AURKAAURKBTSHR
Hydrochloric Acid SCHEMBL27788430 0.77 CDK2 (0.60) TTRCA1CA2CA9CA12
SCHEMBL15851423 0.76 CDK2 (0.70) TTRCA1CA2CA9CA12
SCHEMBL8028660 0.76 TTR (0.72) TTRCA1CA2CA9CDK2
SCHEMBL1502472 0.76 TTR (0.72) TTRCA1CA2CA9CDK2
SCHEMBL305631 0.76 TTR (0.72) TTRCA1CA2CA9CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1455777-A1 GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS SMITHKLINE BEECHAM PLC (GB) 2004-09-15 EP claimed
WO-2003055478-A1 GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS SMITHKLINE BEECHAM P.L.C. (GB) 2003-07-10 WO claimed
EP-1455777-A1 GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS SMITHKLINE BEECHAM PLC (GB) 2004-09-15 EP disclosed
WO-2003055478-A1 GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS SMITHKLINE BEECHAM P.L.C. (GB) 2003-07-10 WO disclosed