SCHEMBL6672544

SCHEMBL6672544

FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)[Si](Cl)(Cl)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F

nearest known ligand 0.38

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.38
THRB P10828 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13231934 1.00 LMNA (0.38) LMNATHRB
SCHEMBL30491871 0.88 LMNA (0.35) LMNA
SCHEMBL28468310 0.88 LMNA (0.35) LMNA
SCHEMBL8573664 0.88 LMNA (0.35) LMNA
SCHEMBL5548622 0.88 LMNA (0.35) LMNA
SCHEMBL1953223 0.88 LMNA (0.35) LMNA
SCHEMBL8209624 0.88 LMNA (0.35) LMNA
SCHEMBL28927565 0.85 LMNA (0.30) LMNA
SCHEMBL366936 0.81 LMNA (0.38) LMNATHRB
SCHEMBL64546 0.81 LMNA (0.38) LMNATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1220860-B1 NOVEL FLUOROALKYLSUBSTITUTED CYCLOTRISILOXANES, THEIR USE FOR PREPARATION OF NEW POLYMERS AND NOVEL POLYMERS UNIV SOUTHERN CALIFORNIA (US) 2004-09-22 EP disclosed
EP-1220860-A1 NOVEL FLUOROALKYLSUBSTITUTED CYCLOTRISILOXANES, THEIR USE FOR PREPARATION OF NEW POLYMERS AND NOVEL POLYMERS THE UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2002-07-10 EP disclosed
US-6291623-B1 FOR PREPARING POLYSILOXANES UNIVERSITY OF SOUTHERN CALIFORNIA 2001-09-18 US disclosed
WO-2001027121-A1 NOVEL FLUOROALKYLSUBSTITUTED CYCLOTRISILOXANES, THEIR USE FOR PREPARATION OF NEW POLYMERS AND NOVEL POLYMERS UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2001-04-19 WO disclosed