Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | GUSB | P08236 | 1/20 | 0.33 |
| ▸ | LCLAT1 | Q6UWP7 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6403481 | 0.75 | MAPT (0.38) | MAPTLMNASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL6403478 | 0.75 | MAPT (0.38) | MAPTLMNASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL6450386 | 0.70 | CETP (0.38) | MAPTLMNASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL6407908 | 0.69 | MAPT (0.40) | MAPTLMNASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL6407905 | 0.69 | MAPT (0.40) | MAPTLMNASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL26110 | 0.68 | LMNA (0.44) | MAPTLMNASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL25762 | 0.68 | LMNA (0.43) | MAPTLMNASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL25763 | 0.68 | LMNA (0.43) | MAPTLMNASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL7200664 | 0.66 | CYP1A2 (0.41) | MAPTLMNASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL24652 | 0.66 | LMNA (0.43) | MAPTLMNASMN1; SMN2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411933-A1 | ALPHA-KETOAMIDE DERIVATIVES AS CATHEPSIN K INHIBITORS | SmithKline Beecham Corporation (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003013518-A1 | ALPHA-KETOAMIDE DERIVATIVES AS CATHEPSIN K INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-02-20 | — | — | WO | disclosed |