Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 2/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.40 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PER2 | O15055 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1929302 | 0.80 | CHRNB4 (0.66) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNA4 | |
| SCHEMBL1928695 | 0.76 | CHRNB4 (0.72) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNA4 | |
| SCHEMBL1928412 | 0.76 | CHRNB4 (0.72) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNA4 | |
| SCHEMBL17596226 | 0.72 | PSEN1 (0.37) | KMT2AALDH1A1PER2CRY1CRY2 | |
| SCHEMBL11448897 | 0.70 | CHRNB4 (0.52) | CHRNB4CHRNA3LMNAKMT2AALDH1A1 | |
| SCHEMBL18586429 | 0.70 | LMNA (0.51) | CHRNB4CHRNA3LMNAKMT2AHPGD | |
| SCHEMBL18615875 | 0.70 | LMNA (0.51) | CHRNB4CHRNA3LMNAKMT2AHPGD | |
| SCHEMBL29642919 | 0.70 | LMNA (0.51) | CHRNB4CHRNA3LMNAKMT2AHPGD | |
| SCHEMBL21949703 | 0.70 | LMNA (0.51) | CHRNB4CHRNA3LMNAKMT2AHPGD | |
| SCHEMBL8224255 | 0.70 | LMNA (0.51) | LMNAKMT2AHPGDHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421074-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2004-05-26 | — | — | EP | disclosed |
| WO-2003010158-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2003-02-06 | — | — | WO | disclosed |