Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | JUN | P05412 | 1/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1233284 | 0.86 | CYP2A6 (0.63) | CYP2A6SMN1; SMN2TP53RXFP1TAAR1 | |
| SCHEMBL10370773 | 0.84 | CYP2A6 (0.66) | CYP2A6SMN1; SMN2TP53RXFP1TAAR1 | |
| Acetic Acid SCHEMBL7564503 | 0.81 | CYP2A6 (0.58) | CYP2A6SMN1; SMN2TP53RXFP1TAAR1 | |
| SCHEMBL6710511 | 0.81 | CYP2A6 (0.61) | CYP2A6SMN1; SMN2TP53RXFP1TAAR1 | |
| SCHEMBL3070140 | 0.81 | CYP2A6 (0.61) | CYP2A6SMN1; SMN2TP53RXFP1TAAR1 | |
| SCHEMBL12174999 | 0.81 | CYP2A6 (0.61) | CYP2A6SMN1; SMN2TP53RXFP1TAAR1 | |
| SCHEMBL6979554 | 0.81 | CYP2A6 (0.61) | CYP2A6SMN1; SMN2TP53RXFP1TAAR1 | |
| SCHEMBL13338100 | 0.78 | CYP2A6 (0.58) | CYP2A6SMN1; SMN2TP53RXFP1TAAR1 | |
| SCHEMBL2248697 | 0.78 | CYP2A6 (0.58) | CYP2A6SMN1; SMN2TP53RXFP1TAAR1 | |
| SCHEMBL12158633 | 0.78 | CYP2A6 (0.58) | CYP2A6SMN1; SMN2TP53RXFP1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040121965-A1 | Method of treating resistant tumors | WYETH HOLDINGS CORPORATION (US) | 2004-06-24 | — | — | US | disclosed |
| WO-2004026293-A2 | HEMIASTERLIN DERIVATIVES FOR TREATING RESISTANT TUMORS | WYETH HOLDINGS CORPORATION (US) | 2004-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040121965-A1 | Method of treating resistant tumors | SLC11A2, VHL, REN | CYP2A6 2950/4885SMN1; SMN2 1481/4885TP53 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.