Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.47 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6673198 | 1.00 | CYP3A4 (0.58) | CYP3A4MAPK1TRPA1SIGMAR1KDM4E | |
| SCHEMBL7444929 | 1.00 | CYP3A4 (0.58) | CYP3A4MAPK1TRPA1SIGMAR1KDM4E | |
| Hydrochloric Acid SCHEMBL10879916 | 0.98 | CYP3A4 (0.57) | CYP3A4MAPK1TRPA1SIGMAR1KDM4E | |
| Hydrochloric Acid SCHEMBL10998387 | 0.98 | CYP3A4 (0.57) | CYP3A4MAPK1TRPA1SIGMAR1KDM4E | |
| L-Phenylalaninol SCHEMBL10878979 | 0.92 | CYP3A4 (0.51) | CYP3A4MAPK1TRPA1SIGMAR1KDM4E | |
| L-Phenylalaninol SCHEMBL10878975 | 0.92 | CYP3A4 (0.51) | CYP3A4MAPK1TRPA1SIGMAR1KDM4E | |
| SCHEMBL7348151 | 0.90 | MAPK1 (0.58) | CYP3A4MAPK1TRPA1SIGMAR1KDM4E | |
| SCHEMBL7345520 | 0.90 | MAPK1 (0.58) | CYP3A4MAPK1TRPA1SIGMAR1KDM4E | |
| SCHEMBL18435245 | 0.85 | CYP3A4 (0.55) | CYP3A4MAPK1TRPA1SIGMAR1KDM4E | |
| SCHEMBL18435381 | 0.85 | CYP3A4 (0.55) | CYP3A4MAPK1TRPA1SIGMAR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106458866-A | Aminocarbonyl carbamate compound | 爱思开生物制药株式会社 | 2017-02-22 | — | — | CN | claimed |
| EP-0105696-B1 | OPTICALLY ACTIVE N-SUBSTITUTED PHENYLALANINOLS AND USE THEREFOR | Dainippon Pharmaceutical Co., Ltd. (JP) | 1986-01-02 | — | — | EP | claimed |
| EP-0105696-A1 | Optically active N-substituted phenylalaninols and use therefor | Dainippon Pharmaceutical Co., Ltd. (JP) | 1984-04-18 | — | — | EP | claimed |
| US-20230167104-A1 | NEW IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2023-06-01 | — | — | US | disclosed |
| WO-2021219828-A1 | NEW IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2021-11-04 | — | — | WO | disclosed |
| US-10723727-B2 | Tubulysin analogs and methods for their preparation | PFIZER INC. (US) | 2020-07-28 | — | — | US | disclosed |
| EP-2861581-B9 | 1,2,3,4-Tetrahydroisoquinoline-pyrrolidine derivatives as antagonists of apoptosis (IAPs) for the treatment of cancer. | BRISTOL MYERS SQUIBB CO (US) | 2017-08-30 | — | — | EP | disclosed |
| WO-2017134547-A1 | TUBULYSIN ANALOGS AND METHODS FOR THEIR PREPARATION | PFIZER INC. (US) | 2017-08-10 | — | — | WO | disclosed |
| CN-106458866-A | Aminocarbonyl carbamate compound | 爱思开生物制药株式会社 | 2017-02-22 | — | — | CN | disclosed |
| EP-2861581-B1 | 1,2,3,4-Tetrahydroisoquinoline-pyrrolidine derivatives as antagonists of apoptosis (IAPs) for the treatment of cancer. | BRISTOL MYERS SQUIBB CO (US) | 2017-02-01 | — | — | EP | disclosed |
| US-7459460-B2 | Trisubstituted heteroaromatic compounds as calcium sensing receptor modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-12-02 | — | — | US | disclosed |
| EP-0937714-B1 | Process for the preparation of an optically active indoline-2-carboxylic acid or derivative thereof | DSM IP ASSETS BV (NL) | 2004-10-06 | — | — | EP | disclosed |
| EP-0906900-B1 | A process for preparing optically active 2-hydroxy-methyl-3-phenylpropionic acid | AJINOMOTO KK (JP) | 2002-01-23 | — | — | EP | disclosed |
| US-6093846-A | BY REACTING WITH SPECIFIED OPTICALLY ACTIVE AMINES SUCH AS CIS-1-AMINO-2-INDANOL IN A SOLVENT, PRODUCING TWO DIASTEREOISOMERIC SALTS OF DIFFERING SOLUBILITY, FRACTIONAL CRYSTALLIZATION AND DECOMPOSING THE SALT WITH ALKALI OR ACID | AJINOMOTO CO., INC. (JP) | 2000-07-25 | — | — | US | disclosed |
| US-6028217-A | CHEMICAL INTERMEDIATE FOR RENIN INHIBITOR OR ENKEPHALINASE ENZYME INHIBITOR | AJINOMOTO CO., INC. (JP) | 2000-02-22 | — | — | US | disclosed |
| EP-0937714-A1 | Process for the preparation of an optically active indoline-2-carboxylic acid or derivative thereof | DSM N.V. (NL) | 1999-08-25 | — | — | EP | disclosed |
| EP-0906900-A1 | A process for preparing optically active 2-hydroxy-methyl-3-phenylpropionic acid | Ajinomoto Co., Inc. (JP) | 1999-04-07 | — | — | EP | disclosed |
| WO-1994026719-A1 | MERCAPTO-AMIDE DERIVATIVES USEFUL AS NEUTRAL ENDOPEPTIDASE AND ACE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230167104-A1 | NEW IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | CLK1, CLK2, CLK3 | CYP3A4 4593/4885MAPK1 268/4885TRPA1 2883/4885 |
| US-10723727-B2 | Tubulysin analogs and methods for their preparation | NGLY1, TEK, TEKT1 | CYP3A4 4649/4885MAPK1 3409/4885TRPA1 4835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.