Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.47 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.47 |
| ▸ | PRKX | P51817 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.47 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7345520 | 1.00 | MAPK1 (0.58) | MAPK1CYP3A4KMT2AKDM4EMEN1 | |
| SCHEMBL7444929 | 0.90 | CYP3A4 (0.58) | MAPK1CYP3A4KMT2AKDM4EMEN1 | |
| SCHEMBL6673196 | 0.90 | CYP3A4 (0.58) | MAPK1CYP3A4KMT2AKDM4EMEN1 | |
| SCHEMBL6673198 | 0.90 | CYP3A4 (0.58) | MAPK1CYP3A4KMT2AKDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL10879916 | 0.88 | CYP3A4 (0.57) | MAPK1CYP3A4KMT2AKDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL10998387 | 0.88 | CYP3A4 (0.57) | MAPK1CYP3A4KMT2AKDM4EMEN1 | |
| SCHEMBL18435245 | 0.87 | CYP3A4 (0.55) | MAPK1CYP3A4KMT2AKDM4EMEN1 | |
| SCHEMBL18435381 | 0.87 | CYP3A4 (0.55) | MAPK1CYP3A4KMT2AKDM4EMEN1 | |
| SCHEMBL18332505 | 0.86 | MAPK1 (0.54) | MAPK1CYP3A4KMT2AKDM4EMEN1 | |
| SCHEMBL7350419 | 0.86 | MAPK1 (0.54) | MAPK1CYP3A4KMT2AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5389647-A | A prodrugs as hypotensive agents, treating congestive heart failure, urogenital disorders, vision defects | ABBOTT LABORATORIES (US) | 1995-02-14 | — | — | US | disclosed |
| WO-1992003429-A1 | RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1992-03-05 | — | — | WO | disclosed |