Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.76 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.61 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.61 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.61 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.61 |
| ▸ | MMP1 | P03956 | 8/20 | 0.57 |
| ▸ | MMP2 | P08253 | 8/20 | 0.57 |
| ▸ | MMP9 | P14780 | 8/20 | 0.57 |
| ▸ | NOS2 | P35228 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6673269 | 1.00 | TDP1 (0.76) | TDP1LMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6673273 | 1.00 | TDP1 (0.76) | TDP1LMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL27898809 | 0.87 | TDP1 (1.00) | TDP1LMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3380973 | 0.87 | TDP1 (1.00) | TDP1LMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3380975 | 0.87 | TDP1 (1.00) | TDP1LMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3380977 | 0.87 | TDP1 (1.00) | TDP1LMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL28755618 | 0.85 | TDP1 (0.83) | TDP1LMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6858130 | 0.83 | TDP1 (0.71) | TDP1LMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6858133 | 0.83 | TDP1 (0.71) | TDP1LMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6858135 | 0.83 | TDP1 (0.71) | TDP1LMNACYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6831080-B2 | E.g., 3-(2-fluorophenyl)-N-(1-(3-morpholin-4-yl)phenyl)-propyl)acrylamide; disorders responsive to opening of KCNQ potassium channels; analgesics; migraine, bipolar disorders, anticonvulsants, antiepileptic, anxiolytic agents | BRISTOL-MYERS SQUIBB COMPANY | 2004-12-14 | — | — | US | disclosed |
| EP-1392644-A1 | CINNAMIDE DERIVATIVES AS KCNQ POTASSIUM CHANNEL MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-03-03 | — | — | EP | disclosed |
| US-20030166650-A1 | Cinnamide derivatives as KCNQ potassium channel modulators | BRISTOL-MYERS SQUIBB COMPANY | 2003-09-04 | — | — | US | disclosed |
| WO-2002096858-A1 | CINNAMIDE DERIVATIVES AS KCNQ POTASSIUM CHANNEL MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-12-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166650-A1 | Cinnamide derivatives as KCNQ potassium channel modulators | KCNH2, KCNH3, KCNQ1 | TDP1 4537/4885LMNA 899/4885CYP1A2 1264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.