Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LGALS9 | O00182 | 1/20 | 0.44 |
| ▸ | LGALS1 | P09382 | 1/20 | 0.44 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.44 |
| ▸ | LGALS7; LGALS7B | P47929 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6673470 | 1.00 | LGALS9 (0.44) | LGALS9LGALS1LGALS3LGALS7; LGALS7BTSHR | |
| SCHEMBL1521648 | 0.98 | LGALS9 (0.43) | LGALS9LGALS1LGALS3LGALS7; LGALS7BTSHR | |
| SCHEMBL14110323 | 0.98 | LGALS9 (0.43) | LGALS9LGALS1LGALS3LGALS7; LGALS7BTSHR | |
| SCHEMBL15520933 | 0.98 | LGALS9 (0.43) | LGALS9LGALS1LGALS3LGALS7; LGALS7BTSHR | |
| SCHEMBL14268496 | 0.98 | LGALS9 (0.43) | LGALS9LGALS1LGALS3LGALS7; LGALS7BTSHR | |
| SCHEMBL19591671 | 0.98 | LGALS9 (0.43) | LGALS9LGALS1LGALS3LGALS7; LGALS7BTSHR | |
| SCHEMBL13714182 | 0.98 | LGALS9 (0.43) | LGALS9LGALS1LGALS3LGALS7; LGALS7BTSHR | |
| SCHEMBL14293976 | 0.98 | LGALS9 (0.43) | LGALS9LGALS1LGALS3LGALS7; LGALS7BTSHR | |
| SCHEMBL3780804 | 0.98 | LGALS9 (0.43) | LGALS9LGALS1LGALS3LGALS7; LGALS7BTSHR | |
| SCHEMBL8819195 | 0.92 | ABCB1 (0.42) | LGALS9LGALS1LGALS3LGALS7; LGALS7BTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057831-B1 | Process for the preparation of vinyl pyrimidine derivatives | HOFFMANN LA ROCHE (CH) | 2004-09-22 | — | — | EP | disclosed |
| EP-1060183-B1 | 5'-DEOXYCYTIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6437118-B1 | REACTING 4-AMINO-1H-PYRMIDIN-2-ONE WITH VINYL BORANE IN PRESENCE OF PALLADIUM COMPLEX AND BASE | HOFFMANN-LA ROCHE INC. | 2002-08-20 | — | — | US | disclosed |
| US-6211166-B1 | COADMINISTERED WITH A 5-FLUOROURACIL DERIVATIVE; ANTICARCINOGENIC AGENTS | HOFFMAN-LA ROCHE INC. | 2001-04-03 | — | — | US | disclosed |
| EP-1060183-A1 | 5'-DEOXYCYTIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-12-20 | — | — | EP | disclosed |
| EP-1057831-A2 | Process for the preparation of vinyl pyrimidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2000-12-06 | — | — | EP | disclosed |
| US-6114520-A | ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-09-05 | — | — | US | disclosed |
| WO-1999040099-A1 | 5'-DEOXYCYTIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-08-12 | — | — | WO | disclosed |