Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.36 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | HMGCR | P04035 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | SLC13A5 | Q86YT5 | 9/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28185558 | 1.00 | ALDH1A1 (0.60) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| SCHEMBL324871 | 1.00 | ALDH1A1 (0.60) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Hydrochloric Acid SCHEMBL9717842 | 0.98 | ALDH1A1 (0.58) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| SCHEMBL7498202 | 0.98 | ALDH1A1 (0.58) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| SCHEMBL28219199 | 0.98 | ALDH1A1 (0.58) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Ammonia Solution, Strong SCHEMBL8604358 | 0.98 | ALDH1A1 (0.58) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| SCHEMBL20187424 | 0.98 | ALDH1A1 (0.58) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Acetic Acid SCHEMBL16447666 | 0.98 | ALDH1A1 (0.58) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| SCHEMBL21048440 | 0.98 | ALDH1A1 (0.58) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| SCHEMBL28110151 | 0.98 | ALDH1A1 (0.58) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9402762-B2 | Methods and devices for conduit occlusion | FEMASYS INC. | 2016-08-02 | — | — | US | disclosed |
| US-9220880-B2 | Methods and devices for delivery of compositions to conduits | FEMASYS INC. (US) | 2015-12-29 | — | — | US | disclosed |
| US-20150068531-A1 | METHODS AND DEVICES FOR CONDUIT OCCLUSION | FEMASYS INC. (US) | 2015-03-12 | — | — | US | disclosed |
| US-8726906-B2 | Methods and devices for conduit occlusion | FEMASYS INC. (US) | 2014-05-20 | — | — | US | disclosed |
| US-20130225977-A1 | Methods and Devices for Delivery of Compositions to Conduits | FEMASYS INC. (US) | 2013-08-29 | — | — | US | disclosed |
| US-20130220335-A1 | Methods and Devices for Conduit Occlusion | FEMASYS INC. (US) | 2013-08-29 | — | — | US | disclosed |
| US-8336552-B2 | Methods and devices for conduit occlusion | FEMASYS INC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-8324193-B2 | Methods and devices for delivery of compositions to conduits | FEMASYS INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20120042880-A1 | Methods and Devices for Conduit Occlusion | FEMASYS INC. (US) | 2012-02-23 | — | — | US | disclosed |
| US-20120046260-A1 | Methods and Devices for Delivery of Compositions to Conduits | FEMASYS INC. (US) | 2012-02-23 | — | — | US | disclosed |
| US-8052669-B2 | Methods and devices for delivery of compositions to conduits | FEMASYS INC. (US) | 2011-11-08 | — | — | US | disclosed |
| US-8048101-B2 | Methods and devices for conduit occlusion | FEMASYS INC. (US) | 2011-11-01 | — | — | US | disclosed |
| US-20090024155-A1 | Methods and Devices for Conduit Occlusion | FEMASYS, INC. | 2009-01-22 | — | — | US | disclosed |
| US-20090024108-A1 | Methods and Devices for Delivery of Compositions to Conduits | FEMASYS, INC. | 2009-01-22 | — | — | US | disclosed |