Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | LYN | P07948 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.45 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 8/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 3/20 | 0.40 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4082250 | 0.88 | MAPK14 (0.61) | MAPK14ABL1EGFRRAF1LYN | |
| SCHEMBL4087240 | 0.82 | MAPK14 (0.73) | MAPK14ABL1EGFRRAF1LYN | |
| SCHEMBL4086006 | 0.81 | MAPK14 (0.56) | MAPK14ABL1EGFRRAF1LYN | |
| SCHEMBL4081981 | 0.79 | MAPK14 (0.58) | MAPK14ABL1EGFRRAF1LYN | |
| SCHEMBL4081496 | 0.79 | MAPK14 (0.58) | MAPK14GSK3ASRCSYKAHR | |
| SCHEMBL4086002 | 0.78 | MAPK14 (0.57) | MAPK14ABL1EGFRRAF1LYN | |
| SCHEMBL4082162 | 0.77 | MAPK14 (0.70) | MAPK14ABL1EGFRRAF1LYN | |
| SCHEMBL7684243 | 0.77 | MAPK14 (0.58) | MAPK14ABL1EGFRRAF1LYN | |
| SCHEMBL4094268 | 0.76 | MAPK14 (0.66) | MAPK14ABL1EGFRRAF1LYN | |
| SCHEMBL13527349 | 0.76 | MAPK14 (0.85) | MAPK14ABL1EGFRRAF1LYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427412-A1 | METHODS OF TREATING CYTOKINE MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2004-06-16 | — | — | EP | disclosed |
| WO-2003022273-A1 | METHODS OF TREATING CYTOKINE MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2003-03-20 | — | — | WO | disclosed |