Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.58 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | RAF1 | P04049 | 2/20 | 0.44 |
| ▸ | LYN | P07948 | 2/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.44 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | HCK | P08631 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5383745 | 0.88 | MAPK14 (0.46) | MAPK14MAPK12TNFHCKMAPT | |
| SCHEMBL4096218 | 0.81 | MAPK14 (0.87) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4087240 | 0.80 | MAPK14 (0.73) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL7681210 | 0.79 | MAPK14 (0.64) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4082250 | 0.77 | MAPK14 (0.61) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL6674058 | 0.77 | MAPK14 (0.60) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4094268 | 0.75 | MAPK14 (0.66) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL13527349 | 0.75 | MAPK14 (0.85) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL6051674 | 0.74 | MAPK14 (0.82) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4081824 | 0.74 | MAPK14 (0.84) | MAPK14ABL1RAF1LYNMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358945-B1 | CYTOKINE, TUMOR NECROSIS FACTOR, AND INTERLEUKIN INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2002-03-19 | — | — | US | disclosed |