Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTTP | P55157 | 14/20 | 0.47 |
| ▸ | APOB | P04114 | 5/20 | 0.45 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | SMO | Q99835 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7252983 | 0.90 | MTTP (0.49) | MTTPAPOBKDM4EPPARG | |
| SCHEMBL6675077 | 0.90 | MTTP (0.45) | MTTPAPOBTRPV4KDM4EPPARG | |
| SCHEMBL6680330 | 0.89 | MTTP (0.49) | MTTPAPOBKDM4EPPARG | |
| SCHEMBL7040087 | 0.88 | MTTP (0.44) | MTTPAPOBTRPV4PPARG | |
| SCHEMBL6673453 | 0.85 | MTTP (0.49) | MTTPAPOBKDM4EPPARG | |
| SCHEMBL7256228 | 0.84 | MTTP (0.49) | MTTPAPOBPPARG | |
| SCHEMBL6674719 | 0.82 | MTTP (0.49) | MTTPAPOBPPARG | |
| SCHEMBL6675663 | 0.82 | MTTP (0.49) | MTTPAPOBPPARGSMO | |
| SCHEMBL6675775 | 0.82 | CHRNB2 (0.44) | MTTPKDM4EPPARG | |
| SCHEMBL7253319 | 0.81 | MTTP (0.50) | MTTPAPOBKDM4EPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465613-A2 | COMBINATION OF MTP INHIBITORS OR APOB SECRETION INHIBITORS WITH FIBRATES FOR USE AS DRUGS | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003057205-A2 | COMBINATION OF MTP INHIBITORS OR APOB SECRETION INHIBITORS WITH FIBRATES FOR USE AS DRUGS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-07-17 | — | — | WO | disclosed |
| WO-2003004020-A1 | HETEROARYL CARBOXYLIC ACID AMIDES, THE PRODUCTION THEREOF AND THE USE OF THE SAME AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-01-16 | — | — | WO | disclosed |