Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPP5C | P53041 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.34 |
| ▸ | THPO | P40225 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PPM1B | O75688 | 3/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.32 |
| ▸ | PPP1CC | P36873 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | STAT6 | P42226 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11515604 | 0.74 | — | — | |
| SCHEMBL6212412 | 0.72 | PPP5C (0.46) | PPP5CGMNNLMNAPMP22TP53 | |
| SCHEMBL467511 | 0.72 | — | — | |
| SCHEMBL1557414 | 0.72 | TP53 (0.35) | TP53PPM1BPTPN1PPP1CC | |
| SCHEMBL15504683 | 0.71 | — | — | |
| Bicarbonate SCHEMBL10990897 | 0.69 | TFPI2 (0.52) | PPP5CGMNNLMNAPMP22TP53 | |
| SCHEMBL17626919 | 0.69 | LMNA (0.30) | LMNA | |
| SCHEMBL13172737 | 0.66 | — | — | |
| SCHEMBL4391065 | 0.65 | — | — | |
| SCHEMBL13246527 | 0.64 | PPM1B (0.37) | TSHRPPM1BPTPN1PPP1CCCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042422-B1 | LAMINATING ADHESIVE HARDENABLE BY RADIATION AND USE OF SAME | HENKEL KGAA (DE) | 2004-09-29 | — | — | EP | disclosed |