Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL667457 | 1.00 | AGTR2 (0.44) | AGTR2AGTR1 | |
| SCHEMBL994786 | 0.94 | AGTR2 (0.42) | AGTR2AGTR1 | |
| SCHEMBL994431 | 0.92 | AGTR2 (0.45) | AGTR2AGTR1 | |
| SCHEMBL653073 | 0.92 | AGTR2 (0.45) | AGTR2AGTR1 | |
| SCHEMBL650654 | 0.92 | AGTR2 (0.43) | AGTR2AGTR1 | |
| SCHEMBL652670 | 0.90 | AGTR2 (0.42) | AGTR2AGTR1 | |
| SCHEMBL656488 | 0.90 | AGTR2 (0.50) | AGTR2 | |
| SCHEMBL654796 | 0.89 | AGTR2 (0.46) | AGTR2AGTR1 | |
| SCHEMBL656868 | 0.89 | AGTR2 (0.43) | AGTR2AGTR1 | |
| SCHEMBL671768 | 0.89 | AGTR2 (0.47) | AGTR2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451782-A1 | DUAL-ACTING PYRAZOLE ANTIHYPERTENSIVE AGENTS | Theravance, Inc. (US) | 2012-05-16 | — | — | EP | disclosed |
| US-8119634-B2 | Dual-acting pyrazole antihypertensive agents | THERAVANCE, INC. (US) | 2012-02-21 | — | — | US | disclosed |
| WO-2011005674-A1 | DUAL-ACTING PYRAZOLE ANTIHYPERTENSIVE AGENTS | THERAVANCE, INC. (US) | 2011-01-13 | — | — | WO | disclosed |