Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | MIF | P14174 | 1/20 | 0.52 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21003370 | 0.82 | ASIC3 (0.57) | SMN1; SMN2CYP1A2CYP2C9CYP2C19MAPT | |
| SCHEMBL284286 | 0.82 | ASIC3 (0.71) | SMN1; SMN2CYP1A2CYP2C9CYP2C19MAPT | |
| SCHEMBL28218682 | 0.80 | ASIC3 (0.68) | SMN1; SMN2CYP1A2CYP2C9CYP2C19MAPT | |
| SCHEMBL27904874 | 0.80 | ASIC3 (0.68) | SMN1; SMN2CYP1A2CYP2C9CYP2C19MAPT | |
| SCHEMBL29406194 | 0.80 | ASIC3 (0.68) | SMN1; SMN2CYP1A2CYP2C9CYP2C19MAPT | |
| SCHEMBL31121692 | 0.78 | MIF (0.50) | SMN1; SMN2CYP1A2CYP2C9CYP2C19KMT2A | |
| SCHEMBL27871811 | 0.78 | HPGD (0.45) | SMN1; SMN2CYP1A2CYP2C9CYP2C19MAPT | |
| SCHEMBL1444761 | 0.78 | MIF (0.56) | SMN1; SMN2CYP1A2CYP2C9CYP2C19MAPT | |
| SCHEMBL28023205 | 0.78 | ASIC3 (0.61) | SMN1; SMN2CYP1A2CYP2C9CYP2C19MAPT | |
| SCHEMBL18731738 | 0.78 | ASIC3 (0.65) | SMN1; SMN2CYP1A2CYP2C9CYP2C19MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077950-B1 | NOVEL DIPHENYL-SUBSTITUTED 6-RING-HETEROCYCLES, METHODS FOR PRODUCING THEM AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-09-22 | — | — | EP | disclosed |
| US-6235738-B1 | BRAIN DISORDERS; ANTIISCHEMIC AGENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-05-22 | — | — | US | disclosed |
| EP-1077950-A1 | NOVEL DIPHENYL-SUBSTITUTED 6-RING-HETEROCYCLES, METHODS FOR PRODUCING THEM AND THEIR USE AS MEDICAMENTS | Boehringer Ingelheim Pharma KG (DE) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999054311-A1 | NOVEL DIPHENYL-SUBSTITUTED 6-RING-HETEROCYCLES, METHODS FOR PRODUCING THEM AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-10-28 | — | — | WO | disclosed |