SCHEMBL6674834

SCHEMBL6674834

O=c1ccccn1-c1cc(-c2cccnc2)cc(-c2ccccn2)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 6/20 0.57
GRM5 P41594 2/20 0.47
PIM1 P11309 1/20 0.44
PIM2 Q9P1W9 1/20 0.44
GLO1 Q04760 1/20 0.43
CYP19A1 P11511 1/20 0.41
NPC1 O15118 1/20 0.40
TP53 P04637 1/20 0.40
PKM P14618 1/20 0.40
TSHR P16473 1/20 0.40
RAB9A P51151 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
DCTPP1 Q9H773 1/20 0.40
MAPT P10636 1/20 0.40
CYP2E1 P05181 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2B6 P20813 1/20 0.39
CYP2C19 P33261 1/20 0.39
KDR P35968 1/20 0.38
CYP3A4 P08684 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3667467 0.88 GRM5 (0.42) CYP2A6GRM5NPC1RAB9AMAPT
SCHEMBL12068486 0.82 CYP2A6 (0.79) CYP2A6GRM5PIM1PIM2CYP19A1
SCHEMBL3672898 0.80 PDE4D (0.38) CYP2A6GRM5NPC1PKMRAB9A
SCHEMBL14297251 0.79 CYP2A6 (0.73) CYP2A6GRM5PIM1PIM2CYP19A1
SCHEMBL21168167 0.79 CYP2A6 (0.73) CYP2A6GRM5PIM1PIM2CYP19A1
SCHEMBL18074830 0.79 GRM5 (0.37) CYP2A6GRM5NPC1RAB9ADCTPP1
SCHEMBL3666593 0.79 GRM5 (0.38) CYP2A6GRM5
SCHEMBL3677987 0.78 ERN1 (0.40) CYP2A6GRM5TSHRSMN1; SMN2MAPT
SCHEMBL3665776 0.78 GRM5 (0.48) GRM5DCTPP1
SCHEMBL3667343 0.78 GRM5 (0.47) GRM5SMN1; SMN2DCTPP1MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1465626-A2 PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES Eisai Co., Ltd. (JP) 2004-10-13 EP disclosed
WO-2003047577-A2 PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES EISAI CO LTD (JP) 2003-06-12 WO disclosed