SCHEMBL6675265

SCHEMBL6675265

COc1ccc2c(C(F)(F)F)c([N+](=O)[O-])c(=O)[nH]c2c1OC

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 2/20 0.47
NQO2 P16083 2/20 0.47
GRIN2D O15399 3/20 0.43
GRIN3B O60391 3/20 0.43
GRIN1 Q05586 3/20 0.43
GRIN2A Q12879 3/20 0.43
GRIN2B Q13224 3/20 0.43
GRIN2C Q14957 3/20 0.43
GRIN3A Q8TCU5 3/20 0.43
KMT2A Q03164 5/20 0.40
ALDH1A1 P00352 1/20 0.38
MMP2 P08253 1/20 0.38
MMP9 P14780 1/20 0.38
MMP8 P22894 1/20 0.38
MMP13 P45452 1/20 0.38
MEN1 O00255 4/20 0.38
CA12 O43570 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA9 Q16790 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6680413 0.80 CYP19A1 (0.48) CYP19A1NQO2GRIN2DGRIN3BGRIN1
SCHEMBL6675262 0.76 KDM4E (0.56) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL6678542 0.71 NQO2 (0.65) CYP19A1NQO2ALDH1A1
SCHEMBL6682273 0.71 NQO2 (0.44) CYP19A1NQO2ALDH1A1KDM4ETDP1
SCHEMBL6679445 0.68 KMT2A (0.40) KMT2AALDH1A1MEN1SMN1; SMN2POLB
SCHEMBL10954823 0.67 CYP19A1 (0.58) CYP19A1NQO2GRIN2DGRIN3BGRIN1
SCHEMBL28215127 0.67 TDP1 (0.56) CYP19A1KMT2AALDH1A1MEN1SMN1; SMN2
SCHEMBL28396699 0.65 TP53 (0.50) KMT2AALDH1A1MEN1SMN1; SMN2KDM4E
SCHEMBL1179747 0.65 TDP1 (0.62) CYP19A1KMT2AALDH1A1MEN1SMN1; SMN2
SCHEMBL29396391 0.65 TDP1 (0.62) CYP19A1KMT2AALDH1A1MEN1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1181341-B1 LUMINESCENT 4-TRIFLUOROMETHYL-2-QUINOLONES WITH LONG-WAVE UV-ABSORPTION AND THE USE THEREOF URAY GEORG (AT) 2004-10-27 EP disclosed
EP-1181341-A2 LUMINESCENT 4-TRIFLUOROMETHYL-2-QUINOLONES WITH LONG-WAVE UV-ABSORPTION AND THE USE THEREOF Uray, Georg (AT) 2002-02-27 EP disclosed
WO-2000066680-A2 LUMINESCENT 4-TRIFLUOROMETHYL-2-QUINOLONES WITH LONG-WAVE UV-ABSORPTION AND THE USE THEREOF URAY GEORG (AT) 2000-11-09 WO disclosed