Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.62 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.62 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | AHCY | P23526 | 1/20 | 0.56 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6681153 | 0.92 | ADORA2A (0.55) | ADORA2AADORA3ADORA1ADORA2BHIF1A | |
| SCHEMBL6681322 | 0.89 | ADORA2A (0.58) | ADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL6677191 | 0.88 | ADORA3 (0.57) | ADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL12547506 | 0.87 | ADORA2A (0.64) | ADORA2AADORA3ADORA1ADORA2BTMEM97 | |
| SCHEMBL3428044 | 0.87 | ADORA2A (0.81) | ADORA2AADORA3ADORA1ADORA2BHIF1A | |
| SCHEMBL14148591 | 0.87 | ADORA2A (0.81) | ADORA2AADORA3ADORA1ADORA2BHIF1A | |
| SCHEMBL13296309 | 0.87 | ADORA2A (0.81) | ADORA2AADORA3ADORA1ADORA2BHIF1A | |
| SCHEMBL2113766 | 0.87 | ADORA2A (0.81) | ADORA2AADORA3ADORA1ADORA2BHIF1A | |
| SCHEMBL12359573 | 0.87 | ADORA2A (0.64) | ADORA2AADORA3ADORA1ADORA2BTMEM97 | |
| SCHEMBL13777768 | 0.87 | ADORA2A (0.81) | ADORA2AADORA3ADORA1ADORA2BHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1434782-A2 | 2-PROPYNYL ADENOSINE ANALOGS HAVING A2A AGONIST ACTIVITY AND COMPOSITIONS THEREOF | University of Virginia Patent Foundation (US) | 2004-07-07 | — | — | EP | disclosed |
| WO-2003029264-A2 | 2-PROPYNYL ADENOSINE ANALOGS HAVING A2A AGONIST ACTIVITY AND COMPOSITIONS THEREOF | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2003-04-10 | — | — | WO | disclosed |